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Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases
The extent to which evolutionary changes have impacted the phenotypic relationships among human diseases remains unclear. In this work, we report that phenotypically similar diseases are connected by the evolutionary constraints on human disease genes. Human disease groups can be classified into slo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477654/ https://www.ncbi.nlm.nih.gov/pubmed/23091697 http://dx.doi.org/10.1038/srep00757 |