A minimal ligand binding pocket within a network of correlated mutations identified by multiple sequence and structural analysis of G protein coupled receptors

BACKGROUND: G protein coupled receptors (GPCRs) are seven helical transmembrane proteins that function as signal transducers. They bind ligands in their extracellular and transmembrane regions and activate cognate G proteins at their intracellular surface at the other side of the membrane. The relay...

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Detalles Bibliográficos
Autores principales: Moitra, Subhodeep, Tirupula, Kalyan C, Klein-Seetharaman, Judith, Langmead, Christopher James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478154/
https://www.ncbi.nlm.nih.gov/pubmed/22748306
http://dx.doi.org/10.1186/2046-1682-5-13

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