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Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
OBJECTIVE: To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS: A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS: A 41-year-old man with multifocal cutaneous LCS involving the inguina and wa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478178/ https://www.ncbi.nlm.nih.gov/pubmed/22889043 http://dx.doi.org/10.1186/1746-1596-7-99 |
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author | Wang, Changsong Chen, Yanping Gao, Chunfang Yin, Jian Li, Hong |
author_facet | Wang, Changsong Chen, Yanping Gao, Chunfang Yin, Jian Li, Hong |
author_sort | Wang, Changsong |
collection | PubMed |
description | OBJECTIVE: To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS: A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS: A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were available. Neoplastic cells with markedly malignant cytological features were observed. Tumor cells exhibited irregular shape with abundant and eosinophilic red staining cytoplasm; large, irregular-shaped, showing lobulated or dented nucleus and some cells with a longitudinal nuclear groove and prominent nucleoli. The tumor cells expressed CD1a, Langerin (CD207), S-100 protein, CD68 and vimentin, and did not express pan-T or B cell markers and epithelial markers. The patient died less than 1 year after diagnosis due to local recurrence and metastasis to the lung, despite the administration of local radiation and chemotherapy. CONCLUSIONS: LCS is a tumor with markedly malignant cytological features that originates from Langerhans cells. Primary multifocal neoplasms involving epidermis is even rare. Accurate diagnosis is based on the histopathological and immunohistochemical of the tumor cells. VIRTUAL SLIDE: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1182345104754765. |
format | Online Article Text |
id | pubmed-3478178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34781782012-10-23 Multifocal Langerhans cell sarcoma involving epidermis: a case report and review Wang, Changsong Chen, Yanping Gao, Chunfang Yin, Jian Li, Hong Diagn Pathol Case Report OBJECTIVE: To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS: A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS: A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were available. Neoplastic cells with markedly malignant cytological features were observed. Tumor cells exhibited irregular shape with abundant and eosinophilic red staining cytoplasm; large, irregular-shaped, showing lobulated or dented nucleus and some cells with a longitudinal nuclear groove and prominent nucleoli. The tumor cells expressed CD1a, Langerin (CD207), S-100 protein, CD68 and vimentin, and did not express pan-T or B cell markers and epithelial markers. The patient died less than 1 year after diagnosis due to local recurrence and metastasis to the lung, despite the administration of local radiation and chemotherapy. CONCLUSIONS: LCS is a tumor with markedly malignant cytological features that originates from Langerhans cells. Primary multifocal neoplasms involving epidermis is even rare. Accurate diagnosis is based on the histopathological and immunohistochemical of the tumor cells. VIRTUAL SLIDE: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1182345104754765. BioMed Central 2012-08-14 /pmc/articles/PMC3478178/ /pubmed/22889043 http://dx.doi.org/10.1186/1746-1596-7-99 Text en Copyright ©2012 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Wang, Changsong Chen, Yanping Gao, Chunfang Yin, Jian Li, Hong Multifocal Langerhans cell sarcoma involving epidermis: a case report and review |
title | Multifocal Langerhans cell sarcoma involving epidermis: a case report and review |
title_full | Multifocal Langerhans cell sarcoma involving epidermis: a case report and review |
title_fullStr | Multifocal Langerhans cell sarcoma involving epidermis: a case report and review |
title_full_unstemmed | Multifocal Langerhans cell sarcoma involving epidermis: a case report and review |
title_short | Multifocal Langerhans cell sarcoma involving epidermis: a case report and review |
title_sort | multifocal langerhans cell sarcoma involving epidermis: a case report and review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478178/ https://www.ncbi.nlm.nih.gov/pubmed/22889043 http://dx.doi.org/10.1186/1746-1596-7-99 |
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