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Multifocal Langerhans cell sarcoma involving epidermis: a case report and review

OBJECTIVE: To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS: A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS: A 41-year-old man with multifocal cutaneous LCS involving the inguina and wa...

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Autores principales: Wang, Changsong, Chen, Yanping, Gao, Chunfang, Yin, Jian, Li, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478178/
https://www.ncbi.nlm.nih.gov/pubmed/22889043
http://dx.doi.org/10.1186/1746-1596-7-99
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author Wang, Changsong
Chen, Yanping
Gao, Chunfang
Yin, Jian
Li, Hong
author_facet Wang, Changsong
Chen, Yanping
Gao, Chunfang
Yin, Jian
Li, Hong
author_sort Wang, Changsong
collection PubMed
description OBJECTIVE: To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS: A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS: A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were available. Neoplastic cells with markedly malignant cytological features were observed. Tumor cells exhibited irregular shape with abundant and eosinophilic red staining cytoplasm; large, irregular-shaped, showing lobulated or dented nucleus and some cells with a longitudinal nuclear groove and prominent nucleoli. The tumor cells expressed CD1a, Langerin (CD207), S-100 protein, CD68 and vimentin, and did not express pan-T or B cell markers and epithelial markers. The patient died less than 1 year after diagnosis due to local recurrence and metastasis to the lung, despite the administration of local radiation and chemotherapy. CONCLUSIONS: LCS is a tumor with markedly malignant cytological features that originates from Langerhans cells. Primary multifocal neoplasms involving epidermis is even rare. Accurate diagnosis is based on the histopathological and immunohistochemical of the tumor cells. VIRTUAL SLIDE: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1182345104754765.
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spelling pubmed-34781782012-10-23 Multifocal Langerhans cell sarcoma involving epidermis: a case report and review Wang, Changsong Chen, Yanping Gao, Chunfang Yin, Jian Li, Hong Diagn Pathol Case Report OBJECTIVE: To study the clinico-pathological characteristics of Langerhans cell sarcoma (LCS) which involving epidermis. METHODS: A case of primary multifocal LCS was analyzed in histopathology and immunophenotype. RESULTS: A 41-year-old man with multifocal cutaneous LCS involving the inguina and waist was reported. Clinical and pathology data were available. Neoplastic cells with markedly malignant cytological features were observed. Tumor cells exhibited irregular shape with abundant and eosinophilic red staining cytoplasm; large, irregular-shaped, showing lobulated or dented nucleus and some cells with a longitudinal nuclear groove and prominent nucleoli. The tumor cells expressed CD1a, Langerin (CD207), S-100 protein, CD68 and vimentin, and did not express pan-T or B cell markers and epithelial markers. The patient died less than 1 year after diagnosis due to local recurrence and metastasis to the lung, despite the administration of local radiation and chemotherapy. CONCLUSIONS: LCS is a tumor with markedly malignant cytological features that originates from Langerhans cells. Primary multifocal neoplasms involving epidermis is even rare. Accurate diagnosis is based on the histopathological and immunohistochemical of the tumor cells. VIRTUAL SLIDE: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1182345104754765. BioMed Central 2012-08-14 /pmc/articles/PMC3478178/ /pubmed/22889043 http://dx.doi.org/10.1186/1746-1596-7-99 Text en Copyright ©2012 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wang, Changsong
Chen, Yanping
Gao, Chunfang
Yin, Jian
Li, Hong
Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
title Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
title_full Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
title_fullStr Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
title_full_unstemmed Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
title_short Multifocal Langerhans cell sarcoma involving epidermis: a case report and review
title_sort multifocal langerhans cell sarcoma involving epidermis: a case report and review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478178/
https://www.ncbi.nlm.nih.gov/pubmed/22889043
http://dx.doi.org/10.1186/1746-1596-7-99
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