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Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

BACKGROUND: Coal workers' pneumoconiosis (CWP), resulting from the inhalation of silica-containing coal mine dust, is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Recently, it has been hypothesized that inflammasomes could have a crucia...

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Autores principales: Ji, Xiaoming, Hou, Zhiguo, Wang, Ting, Jin, Kexin, Fan, Jingjing, Luo, Chen, Chen, Minjuan, Han, Ruhui, Ni, Chunhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478280/
https://www.ncbi.nlm.nih.gov/pubmed/23110140
http://dx.doi.org/10.1371/journal.pone.0047949
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author Ji, Xiaoming
Hou, Zhiguo
Wang, Ting
Jin, Kexin
Fan, Jingjing
Luo, Chen
Chen, Minjuan
Han, Ruhui
Ni, Chunhui
author_facet Ji, Xiaoming
Hou, Zhiguo
Wang, Ting
Jin, Kexin
Fan, Jingjing
Luo, Chen
Chen, Minjuan
Han, Ruhui
Ni, Chunhui
author_sort Ji, Xiaoming
collection PubMed
description BACKGROUND: Coal workers' pneumoconiosis (CWP), resulting from the inhalation of silica-containing coal mine dust, is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Recently, it has been hypothesized that inflammasomes could have a crucial role in the host response to silica and recent studies show that the inflammasome contributes to inflammation and pulmonary fibrosis. NLRP3, CARD8 are components of the NLRP3 inflammasome, which triggers caspase 1-mediated IL-1β and IL-18 release. In the present study, we investigated whether common single nucleotide polymorphisms (SNPs) in inflammasome genes are associated with CWP. METHODS: We performed an association study analyzing 3 NLRP3, 1 CARD8, 1 IL-1β, 2 IL-18 SNPs in a case-control study of 697 CWP and 694 controls. Genotyping was carried out by the TaqMan method. RESULTS: The NLRP3 rs1539019 TT genotype was associated with a significantly increased risk of CWP (adjusted odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.07–1.81), compared with the GG/GT genotype, in particular among smokers (adjusted OR = 1.67, 95%CI = 1.15–2.42). In addition, the polymorphism was significantly associated with risk of CWP patients with stage I. CONCLUSIONS: This is the first report showing an association between the NLRP3 rs1539019 polymorphism and CWP, and suggests that this polymorphism may confer increased risk for the development of the disease. Further studies are warranted to confirm our findings.
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spelling pubmed-34782802012-10-29 Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population Ji, Xiaoming Hou, Zhiguo Wang, Ting Jin, Kexin Fan, Jingjing Luo, Chen Chen, Minjuan Han, Ruhui Ni, Chunhui PLoS One Research Article BACKGROUND: Coal workers' pneumoconiosis (CWP), resulting from the inhalation of silica-containing coal mine dust, is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Recently, it has been hypothesized that inflammasomes could have a crucial role in the host response to silica and recent studies show that the inflammasome contributes to inflammation and pulmonary fibrosis. NLRP3, CARD8 are components of the NLRP3 inflammasome, which triggers caspase 1-mediated IL-1β and IL-18 release. In the present study, we investigated whether common single nucleotide polymorphisms (SNPs) in inflammasome genes are associated with CWP. METHODS: We performed an association study analyzing 3 NLRP3, 1 CARD8, 1 IL-1β, 2 IL-18 SNPs in a case-control study of 697 CWP and 694 controls. Genotyping was carried out by the TaqMan method. RESULTS: The NLRP3 rs1539019 TT genotype was associated with a significantly increased risk of CWP (adjusted odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.07–1.81), compared with the GG/GT genotype, in particular among smokers (adjusted OR = 1.67, 95%CI = 1.15–2.42). In addition, the polymorphism was significantly associated with risk of CWP patients with stage I. CONCLUSIONS: This is the first report showing an association between the NLRP3 rs1539019 polymorphism and CWP, and suggests that this polymorphism may confer increased risk for the development of the disease. Further studies are warranted to confirm our findings. Public Library of Science 2012-10-22 /pmc/articles/PMC3478280/ /pubmed/23110140 http://dx.doi.org/10.1371/journal.pone.0047949 Text en © 2012 Ji et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ji, Xiaoming
Hou, Zhiguo
Wang, Ting
Jin, Kexin
Fan, Jingjing
Luo, Chen
Chen, Minjuan
Han, Ruhui
Ni, Chunhui
Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population
title Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population
title_full Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population
title_fullStr Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population
title_full_unstemmed Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population
title_short Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population
title_sort polymorphisms in inflammasome genes and risk of coal workers' pneumoconiosis in a chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478280/
https://www.ncbi.nlm.nih.gov/pubmed/23110140
http://dx.doi.org/10.1371/journal.pone.0047949
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