Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral adipose tissue–derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from E...

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Detalles Bibliográficos
Autores principales: Nakatsuka, Atsuko, Wada, Jun, Iseda, Izumi, Teshigawara, Sanae, Higashio, Kanji, Murakami, Kazutoshi, Kanzaki, Motoko, Inoue, Kentaro, Terami, Takahiro, Katayama, Akihiro, Hida, Kazuyuki, Eguchi, Jun, Horiguchi, Chikage Sato, Ogawa, Daisuke, Matsuki, Yasushi, Hiramatsu, Ryuji, Yagita, Hideo, Kakuta, Shigeru, Iwakura, Yoichiro, Makino, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478540/
https://www.ncbi.nlm.nih.gov/pubmed/22837305
http://dx.doi.org/10.2337/db12-0232

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