Cargando…

Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass

Type 2 diabetes (T2D) results from insulin resistance and inadequate insulin secretion. Insulin resistance initially causes compensatory islet hyperplasia that progresses to islet disorganization and altered vascularization, inflammation, and, finally, decreased functional β-cell mass and hyperglyce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agudo, Judith, Ayuso, Eduard, Jimenez, Veronica, Casellas, Alba, Mallol, Cristina, Salavert, Ariana, Tafuro, Sabrina, Obach, Mercè, Ruzo, Albert, Moya, Marta, Pujol, Anna, Bosch, Fatima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478542/ https://www.ncbi.nlm.nih.gov/pubmed/22961079 http://dx.doi.org/10.2337/db12-0134

Ejemplares similares

Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice
por: Anguela, Xavier M., et al.
Publicado: (2013)

Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice
por: Morró, Meritxell, et al.
Publicado: (2020)

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
por: Molina, Judith, et al.
Publicado: (2014)

Intracutaneous Transplantation of Islets Within a Biodegradable Temporizing Matrix as an Alternative Site for Islet Transplantation
por: Rojas-Canales, Darling, et al.
Publicado: (2023)

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
por: Hauge-Evans, Astrid C., et al.
Publicado: (2009)

Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization
por: Johansson, Ulrika, et al.
Publicado: (2008)

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
por: Dahan, Tehila, et al.
Publicado: (2017)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
por: Mezza, Teresa, et al.
Publicado: (2014)

Islet-1 Is Essential for Pancreatic β-Cell Function
por: Ediger, Benjamin N., et al.
Publicado: (2014)

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
por: Marzban, Lucy, et al.
Publicado: (2008)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

A Smad Signaling Network Regulates Islet Cell Proliferation
por: El-Gohary, Yousef, et al.
Publicado: (2014)

Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure
por: Hodik, M, et al.
Publicado: (2016)

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2008)

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection
por: Schulte, Barbara M., et al.
Publicado: (2012)

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice
por: He, Kai Hui Hu, et al.
Publicado: (2011)

Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function
por: Olerud, Johan, et al.
Publicado: (2011)

High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets
por: Lamprianou, Smaragda, et al.
Publicado: (2011)

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo
por: Zhu, Shuaishuai, et al.
Publicado: (2016)

Islet inflammation is associated with pancreatic fatty infiltration and hyperglycemia in type 2 diabetes
por: Horii, Tomomi, et al.
Publicado: (2020)

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
por: Deering, Tye G., et al.
Publicado: (2009)

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
por: Dolai, Subhankar, et al.
Publicado: (2016)

Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
por: Tamayo, Alejandro, et al.
Publicado: (2022)

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet
por: Syed, Ismail, et al.
Publicado: (2011)

Switching-On Survival and Repair Response Programs in Islet Transplants by Bone Marrow–Derived Vasculogenic Cells
por: Miller, Robyn, et al.
Publicado: (2008)

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells
por: Dezaki, Katsuya, et al.
Publicado: (2011)

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules
por: Kruit, Janine K., et al.
Publicado: (2011)

Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice
por: Rahman, Muhammad Jubayer, et al.
Publicado: (2014)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

Novel Stable Isotope Analyses Demonstrate Significant Rates of Glucose Cycling in Mouse Pancreatic Islets
por: Wall, Martha L., et al.
Publicado: (2015)

Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
por: Banerjee, Ronadip R., et al.
Publicado: (2016)

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
por: Kato, Toyonori, et al.
Publicado: (2008)

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets
por: Tian, Geng, et al.
Publicado: (2011)

Recovery of Endogenous β-Cell Function in Nonhuman Primates After Chemical Diabetes Induction and Islet Transplantation
por: Bottino, Rita, et al.
Publicado: (2009)

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
por: Korpos, Éva, et al.
Publicado: (2013)

Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats
por: Jaeckle Santos, Lane J., et al.
Publicado: (2014)

Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves
por: Mundinger, Thomas O., et al.
Publicado: (2016)

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
por: Rosario, Wilfredo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_686tdpl8irg2p8h9q9vsv0qg97