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How complex are intracellular immune receptor signaling complexes?

Nucleotide binding leucine-rich repeat proteins (NLRs) are the major class of intracellular immune receptors in plants. NLRs typically function to specifically recognize pathogen effectors and to initiate and control defense responses that severely limit pathogen growth in plants (termed effector-tr...

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Detalles Bibliográficos
Autores principales: Bonardi, Vera, Dangl, Jeffery L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478704/
https://www.ncbi.nlm.nih.gov/pubmed/23109935
http://dx.doi.org/10.3389/fpls.2012.00237
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author Bonardi, Vera
Dangl, Jeffery L.
author_facet Bonardi, Vera
Dangl, Jeffery L.
author_sort Bonardi, Vera
collection PubMed
description Nucleotide binding leucine-rich repeat proteins (NLRs) are the major class of intracellular immune receptors in plants. NLRs typically function to specifically recognize pathogen effectors and to initiate and control defense responses that severely limit pathogen growth in plants (termed effector-triggered immunity, or ETI). Despite numerous reports supporting a central role in innate immunity, the molecular mechanisms driving NLR activation and downstream signaling remain largely elusive. Recent reports shed light on the pre- and post-activation dynamics of a few NLR-containing protein complexes. Recent technological advances in the use of proteomics may enable high-resolution definition of immune protein complexes and possible activation-relevant post-translational modifications of the components in these complexes. In this review, we focus on research aimed at characterizing pre- and post-activation NLR protein complexes and the molecular events that follow activation. We discuss the use of new or improved technologies as tools to unveil the molecular mechanisms that define NLR-mediated pathogen recognition.
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spelling pubmed-34787042012-10-29 How complex are intracellular immune receptor signaling complexes? Bonardi, Vera Dangl, Jeffery L. Front Plant Sci Plant Science Nucleotide binding leucine-rich repeat proteins (NLRs) are the major class of intracellular immune receptors in plants. NLRs typically function to specifically recognize pathogen effectors and to initiate and control defense responses that severely limit pathogen growth in plants (termed effector-triggered immunity, or ETI). Despite numerous reports supporting a central role in innate immunity, the molecular mechanisms driving NLR activation and downstream signaling remain largely elusive. Recent reports shed light on the pre- and post-activation dynamics of a few NLR-containing protein complexes. Recent technological advances in the use of proteomics may enable high-resolution definition of immune protein complexes and possible activation-relevant post-translational modifications of the components in these complexes. In this review, we focus on research aimed at characterizing pre- and post-activation NLR protein complexes and the molecular events that follow activation. We discuss the use of new or improved technologies as tools to unveil the molecular mechanisms that define NLR-mediated pathogen recognition. Frontiers Media S.A. 2012-10-23 /pmc/articles/PMC3478704/ /pubmed/23109935 http://dx.doi.org/10.3389/fpls.2012.00237 Text en Copyright © Bonardi and Dangl. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Plant Science
Bonardi, Vera
Dangl, Jeffery L.
How complex are intracellular immune receptor signaling complexes?
title How complex are intracellular immune receptor signaling complexes?
title_full How complex are intracellular immune receptor signaling complexes?
title_fullStr How complex are intracellular immune receptor signaling complexes?
title_full_unstemmed How complex are intracellular immune receptor signaling complexes?
title_short How complex are intracellular immune receptor signaling complexes?
title_sort how complex are intracellular immune receptor signaling complexes?
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478704/
https://www.ncbi.nlm.nih.gov/pubmed/23109935
http://dx.doi.org/10.3389/fpls.2012.00237
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