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Dendritic Cells, Viruses, and the Development of Atopic Disease
Dendritic cells are important residents of the lung environment. They have been associated with asthma and other inflammatory diseases of the airways. In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. While...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478734/ https://www.ncbi.nlm.nih.gov/pubmed/23118777 http://dx.doi.org/10.1155/2012/936870 |
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author | Tam, Jonathan S. Grayson, Mitchell H. |
author_facet | Tam, Jonathan S. Grayson, Mitchell H. |
author_sort | Tam, Jonathan S. |
collection | PubMed |
description | Dendritic cells are important residents of the lung environment. They have been associated with asthma and other inflammatory diseases of the airways. In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. While it has long been known that respiratory viral infections associate with the development and exacerbation of atopic diseases, the exact mechanisms have been unclear. Recent studies have begun to show the critical importance of the dendritic cell in this process. This paper focuses on these data demonstrating how different populations of dendritic cells are capable of bridging the adaptive and innate immune systems, ultimately leading to the translation of viral illness into atopic disease. |
format | Online Article Text |
id | pubmed-3478734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34787342012-11-01 Dendritic Cells, Viruses, and the Development of Atopic Disease Tam, Jonathan S. Grayson, Mitchell H. J Allergy (Cairo) Review Article Dendritic cells are important residents of the lung environment. They have been associated with asthma and other inflammatory diseases of the airways. In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. While it has long been known that respiratory viral infections associate with the development and exacerbation of atopic diseases, the exact mechanisms have been unclear. Recent studies have begun to show the critical importance of the dendritic cell in this process. This paper focuses on these data demonstrating how different populations of dendritic cells are capable of bridging the adaptive and innate immune systems, ultimately leading to the translation of viral illness into atopic disease. Hindawi Publishing Corporation 2012 2012-10-15 /pmc/articles/PMC3478734/ /pubmed/23118777 http://dx.doi.org/10.1155/2012/936870 Text en Copyright © 2012 J. S. Tam and M. H. Grayson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tam, Jonathan S. Grayson, Mitchell H. Dendritic Cells, Viruses, and the Development of Atopic Disease |
title | Dendritic Cells, Viruses, and the Development of Atopic Disease |
title_full | Dendritic Cells, Viruses, and the Development of Atopic Disease |
title_fullStr | Dendritic Cells, Viruses, and the Development of Atopic Disease |
title_full_unstemmed | Dendritic Cells, Viruses, and the Development of Atopic Disease |
title_short | Dendritic Cells, Viruses, and the Development of Atopic Disease |
title_sort | dendritic cells, viruses, and the development of atopic disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478734/ https://www.ncbi.nlm.nih.gov/pubmed/23118777 http://dx.doi.org/10.1155/2012/936870 |
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