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Dendritic Cells, Viruses, and the Development of Atopic Disease

Dendritic cells are important residents of the lung environment. They have been associated with asthma and other inflammatory diseases of the airways. In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. While...

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Detalles Bibliográficos
Autores principales: Tam, Jonathan S., Grayson, Mitchell H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478734/
https://www.ncbi.nlm.nih.gov/pubmed/23118777
http://dx.doi.org/10.1155/2012/936870
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author Tam, Jonathan S.
Grayson, Mitchell H.
author_facet Tam, Jonathan S.
Grayson, Mitchell H.
author_sort Tam, Jonathan S.
collection PubMed
description Dendritic cells are important residents of the lung environment. They have been associated with asthma and other inflammatory diseases of the airways. In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. While it has long been known that respiratory viral infections associate with the development and exacerbation of atopic diseases, the exact mechanisms have been unclear. Recent studies have begun to show the critical importance of the dendritic cell in this process. This paper focuses on these data demonstrating how different populations of dendritic cells are capable of bridging the adaptive and innate immune systems, ultimately leading to the translation of viral illness into atopic disease.
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spelling pubmed-34787342012-11-01 Dendritic Cells, Viruses, and the Development of Atopic Disease Tam, Jonathan S. Grayson, Mitchell H. J Allergy (Cairo) Review Article Dendritic cells are important residents of the lung environment. They have been associated with asthma and other inflammatory diseases of the airways. In addition to their antigen-presenting functions, dendritic cells have the ability to modulate the lung environment to promote atopic disease. While it has long been known that respiratory viral infections associate with the development and exacerbation of atopic diseases, the exact mechanisms have been unclear. Recent studies have begun to show the critical importance of the dendritic cell in this process. This paper focuses on these data demonstrating how different populations of dendritic cells are capable of bridging the adaptive and innate immune systems, ultimately leading to the translation of viral illness into atopic disease. Hindawi Publishing Corporation 2012 2012-10-15 /pmc/articles/PMC3478734/ /pubmed/23118777 http://dx.doi.org/10.1155/2012/936870 Text en Copyright © 2012 J. S. Tam and M. H. Grayson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tam, Jonathan S.
Grayson, Mitchell H.
Dendritic Cells, Viruses, and the Development of Atopic Disease
title Dendritic Cells, Viruses, and the Development of Atopic Disease
title_full Dendritic Cells, Viruses, and the Development of Atopic Disease
title_fullStr Dendritic Cells, Viruses, and the Development of Atopic Disease
title_full_unstemmed Dendritic Cells, Viruses, and the Development of Atopic Disease
title_short Dendritic Cells, Viruses, and the Development of Atopic Disease
title_sort dendritic cells, viruses, and the development of atopic disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478734/
https://www.ncbi.nlm.nih.gov/pubmed/23118777
http://dx.doi.org/10.1155/2012/936870
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