Large Scale Solid Phase Synthesis of Peptide Drugs: Use of Commercial Anion Exchange Resin as Quenching Agent for Removal of Iodine during Disulphide Bond Formation

The S-acetamidomethyl (Acm) or trityl (Trt) protecting groups are widely used in the chemical synthesis of peptides that contain one or more disulfide bonds. Treatment of peptides containing S-Acm protecting group with iodine results in simultaneous removal of the sulfhydryl protecting group and dis...

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Detalles Bibliográficos
Autores principales: Reddy, K. M. Bhaskara, Kumari, Y. Bharathi, Mallikharjunasarma, Dokka, Bulliraju, Kamana, Sreelatha, Vanjivaka, Ananda, Kuppanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478740/
https://www.ncbi.nlm.nih.gov/pubmed/23118772
http://dx.doi.org/10.1155/2012/323907

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