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The Plasminogen System in Regulating Stem Cell Mobilization
The treatment of patients with hematopoietic progenitor and stem cells (HPSCs) to reconstitute hematopoiesis after myeloablative therapy or to repair ischemia after myocardial infarction has significantly improved clinical outcomes. Successful blood or bone marrow transplants require a sufficient nu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478786/ https://www.ncbi.nlm.nih.gov/pubmed/23118508 http://dx.doi.org/10.1155/2012/437920 |
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author | Gong, Yanqing Hoover-Plow, Jane |
author_facet | Gong, Yanqing Hoover-Plow, Jane |
author_sort | Gong, Yanqing |
collection | PubMed |
description | The treatment of patients with hematopoietic progenitor and stem cells (HPSCs) to reconstitute hematopoiesis after myeloablative therapy or to repair ischemia after myocardial infarction has significantly improved clinical outcomes. Successful blood or bone marrow transplants require a sufficient number of HPSCs capable of homing to the injured site to regenerate tissue. Granulocyte-colony stimulating factor (G-CSF) is widely used clinically for stem cell mobilization. However, in some patients the response is poor, thus a better understanding of the mechanisms underlying G-CSF-regulated stem cell mobilization is needed. The pasminogen (Plg) system is the primary fibrinolytic pathway responsible for clot dissolution after thrombosis. Recent evidence suggests that Plg plays a pivotal role in stem cell mobilization from the bone marrow to the peripheral circulation, particularly in HPSC mobilization in response to G-CSF. This paper will discuss the potential mechanisms by which the Plg system regulates stem cell mobilization, focusing on stepwise proteolysis and signal transduction during HPSC egress from their bone marrow niche. Clear elucidation of the underlying mechanisms may lead to the development of new Plg-based therapeutic strategies to improve stem cell mobilization in treating hematological and cardiovascular diseases. |
format | Online Article Text |
id | pubmed-3478786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34787862012-11-01 The Plasminogen System in Regulating Stem Cell Mobilization Gong, Yanqing Hoover-Plow, Jane J Biomed Biotechnol Review Article The treatment of patients with hematopoietic progenitor and stem cells (HPSCs) to reconstitute hematopoiesis after myeloablative therapy or to repair ischemia after myocardial infarction has significantly improved clinical outcomes. Successful blood or bone marrow transplants require a sufficient number of HPSCs capable of homing to the injured site to regenerate tissue. Granulocyte-colony stimulating factor (G-CSF) is widely used clinically for stem cell mobilization. However, in some patients the response is poor, thus a better understanding of the mechanisms underlying G-CSF-regulated stem cell mobilization is needed. The pasminogen (Plg) system is the primary fibrinolytic pathway responsible for clot dissolution after thrombosis. Recent evidence suggests that Plg plays a pivotal role in stem cell mobilization from the bone marrow to the peripheral circulation, particularly in HPSC mobilization in response to G-CSF. This paper will discuss the potential mechanisms by which the Plg system regulates stem cell mobilization, focusing on stepwise proteolysis and signal transduction during HPSC egress from their bone marrow niche. Clear elucidation of the underlying mechanisms may lead to the development of new Plg-based therapeutic strategies to improve stem cell mobilization in treating hematological and cardiovascular diseases. Hindawi Publishing Corporation 2012 2012-10-14 /pmc/articles/PMC3478786/ /pubmed/23118508 http://dx.doi.org/10.1155/2012/437920 Text en Copyright © 2012 Y. Gong and J. Hoover-Plow. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gong, Yanqing Hoover-Plow, Jane The Plasminogen System in Regulating Stem Cell Mobilization |
title | The Plasminogen System in Regulating Stem Cell Mobilization |
title_full | The Plasminogen System in Regulating Stem Cell Mobilization |
title_fullStr | The Plasminogen System in Regulating Stem Cell Mobilization |
title_full_unstemmed | The Plasminogen System in Regulating Stem Cell Mobilization |
title_short | The Plasminogen System in Regulating Stem Cell Mobilization |
title_sort | plasminogen system in regulating stem cell mobilization |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478786/ https://www.ncbi.nlm.nih.gov/pubmed/23118508 http://dx.doi.org/10.1155/2012/437920 |
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