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Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen

B cell tolerance to self-antigen is critical to preventing antibody-mediated autoimmunity. Previous work using B cell antigen receptor transgenic animals suggested that self-antigen–specific B cells are either deleted from the repertoire, enter a state of diminished function termed anergy, or are ig...

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Detalles Bibliográficos
Autores principales:	Taylor, Justin J., Martinez, Ryan J., Titcombe, Philip J., Barsness, Laura O., Thomas, Stephanie R., Zhang, Na, Katzman, Shoshana D., Jenkins, Marc K., Mueller, Daniel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478923/ https://www.ncbi.nlm.nih.gov/pubmed/23071255 http://dx.doi.org/10.1084/jem.20112272

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