Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

One component of memory in the antibody system is long-lived memory B cells selected for the expression of somatically mutated, high-affinity antibodies in the T cell–dependent germinal center (GC) reaction. A puzzling observation has been that the memory B cell compartment also contains cells expre...

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Detalles Bibliográficos
Autores principales: Kaji, Tomohiro, Ishige, Akiko, Hikida, Masaki, Taka, Junko, Hijikata, Atsushi, Kubo, Masato, Nagashima, Takeshi, Takahashi, Yoshimasa, Kurosaki, Tomohiro, Okada, Mariko, Ohara, Osamu, Rajewsky, Klaus, Takemori, Toshitada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478929/
https://www.ncbi.nlm.nih.gov/pubmed/23027924
http://dx.doi.org/10.1084/jem.20120127

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