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Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

Innate immune detection of nucleic acids is important for initiation of antiviral responses. Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome. Certain members of the AIM2-like receptor (ALR) gene family contribute to each of these...

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Detalles Bibliográficos
Autores principales:	Brunette, Rebecca L., Young, Janet M., Whitley, Deborah G., Brodsky, Igor E., Malik, Harmit S., Stetson, Daniel B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478938/ https://www.ncbi.nlm.nih.gov/pubmed/23045604 http://dx.doi.org/10.1084/jem.20121960

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