Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review

Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this re...

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Detalles Bibliográficos
Autores principales: Hu, Xiaoxia, Chen, Haiying, Jin, Meishan, Wang, Xianfu, Lee, Jiyun, Xu, Weihong, Zhang, Rui, Li, Shibo, Niu, Junqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478990/
https://www.ncbi.nlm.nih.gov/pubmed/22551002
http://dx.doi.org/10.1186/1755-8166-5-26
Descripción
Sumario:Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.

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