Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review

Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this re...

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Autores principales: Hu, Xiaoxia, Chen, Haiying, Jin, Meishan, Wang, Xianfu, Lee, Jiyun, Xu, Weihong, Zhang, Rui, Li, Shibo, Niu, Junqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478990/
https://www.ncbi.nlm.nih.gov/pubmed/22551002
http://dx.doi.org/10.1186/1755-8166-5-26
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author Hu, Xiaoxia
Chen, Haiying
Jin, Meishan
Wang, Xianfu
Lee, Jiyun
Xu, Weihong
Zhang, Rui
Li, Shibo
Niu, Junqi
author_facet Hu, Xiaoxia
Chen, Haiying
Jin, Meishan
Wang, Xianfu
Lee, Jiyun
Xu, Weihong
Zhang, Rui
Li, Shibo
Niu, Junqi
author_sort Hu, Xiaoxia
collection PubMed
description Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies.
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spelling pubmed-34789902012-10-24 Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review Hu, Xiaoxia Chen, Haiying Jin, Meishan Wang, Xianfu Lee, Jiyun Xu, Weihong Zhang, Rui Li, Shibo Niu, Junqi Mol Cytogenet Case Report Undifferentiated embryonal sarcoma of the liver (UESL) represents a heterogeneous group of tumors derived from mesenchymal tissues. Earlier cytogenetic studies in limited cases demonstrated that UESL is associated with a recurrent translocation t(11;19)(q11;q13.3-q13.4) or add(19)(q13.4). In this report, we present our array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with UESL. The data were compared to laboratory findings reported by previous studies. BioMed Central 2012-05-03 /pmc/articles/PMC3478990/ /pubmed/22551002 http://dx.doi.org/10.1186/1755-8166-5-26 Text en Copyright ©2012 Hu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hu, Xiaoxia
Chen, Haiying
Jin, Meishan
Wang, Xianfu
Lee, Jiyun
Xu, Weihong
Zhang, Rui
Li, Shibo
Niu, Junqi
Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
title Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
title_full Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
title_fullStr Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
title_full_unstemmed Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
title_short Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
title_sort molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478990/
https://www.ncbi.nlm.nih.gov/pubmed/22551002
http://dx.doi.org/10.1186/1755-8166-5-26
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