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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between...

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Autores principales: Chen, Sijia, JM de Craen, Anton, Raz, Yotam, Derhovanessian, Evelyna, Vossen CTM, Ann, Westendorp GJ, Rudi, Pawelec, Graham, Maier, Andrea B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478991/
https://www.ncbi.nlm.nih.gov/pubmed/22929089
http://dx.doi.org/10.1186/1742-4933-9-18
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author Chen, Sijia
JM de Craen, Anton
Raz, Yotam
Derhovanessian, Evelyna
Vossen CTM, Ann
Westendorp GJ, Rudi
Pawelec, Graham
Maier, Andrea B
author_facet Chen, Sijia
JM de Craen, Anton
Raz, Yotam
Derhovanessian, Evelyna
Vossen CTM, Ann
Westendorp GJ, Rudi
Pawelec, Graham
Maier, Andrea B
author_sort Chen, Sijia
collection PubMed
description BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
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spelling pubmed-34789912012-10-24 Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study Chen, Sijia JM de Craen, Anton Raz, Yotam Derhovanessian, Evelyna Vossen CTM, Ann Westendorp GJ, Rudi Pawelec, Graham Maier, Andrea B Immun Ageing Research BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly. BioMed Central 2012-08-28 /pmc/articles/PMC3478991/ /pubmed/22929089 http://dx.doi.org/10.1186/1742-4933-9-18 Text en Copyright ©2012 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Chen, Sijia
JM de Craen, Anton
Raz, Yotam
Derhovanessian, Evelyna
Vossen CTM, Ann
Westendorp GJ, Rudi
Pawelec, Graham
Maier, Andrea B
Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
title Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
title_full Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
title_fullStr Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
title_full_unstemmed Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
title_short Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
title_sort cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. results from the leiden 85-plus study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478991/
https://www.ncbi.nlm.nih.gov/pubmed/22929089
http://dx.doi.org/10.1186/1742-4933-9-18
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