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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478991/ https://www.ncbi.nlm.nih.gov/pubmed/22929089 http://dx.doi.org/10.1186/1742-4933-9-18 |
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author | Chen, Sijia JM de Craen, Anton Raz, Yotam Derhovanessian, Evelyna Vossen CTM, Ann Westendorp GJ, Rudi Pawelec, Graham Maier, Andrea B |
author_facet | Chen, Sijia JM de Craen, Anton Raz, Yotam Derhovanessian, Evelyna Vossen CTM, Ann Westendorp GJ, Rudi Pawelec, Graham Maier, Andrea B |
author_sort | Chen, Sijia |
collection | PubMed |
description | BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly. |
format | Online Article Text |
id | pubmed-3478991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34789912012-10-24 Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study Chen, Sijia JM de Craen, Anton Raz, Yotam Derhovanessian, Evelyna Vossen CTM, Ann Westendorp GJ, Rudi Pawelec, Graham Maier, Andrea B Immun Ageing Research BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly. BioMed Central 2012-08-28 /pmc/articles/PMC3478991/ /pubmed/22929089 http://dx.doi.org/10.1186/1742-4933-9-18 Text en Copyright ©2012 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Chen, Sijia JM de Craen, Anton Raz, Yotam Derhovanessian, Evelyna Vossen CTM, Ann Westendorp GJ, Rudi Pawelec, Graham Maier, Andrea B Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
title | Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
title_full | Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
title_fullStr | Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
title_full_unstemmed | Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
title_short | Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
title_sort | cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. results from the leiden 85-plus study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478991/ https://www.ncbi.nlm.nih.gov/pubmed/22929089 http://dx.doi.org/10.1186/1742-4933-9-18 |
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