Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

BACKGROUND: The intracellular deposition of misfolded proteins is a common neuropathological hallmark of most neurodegenerative disorders. Increasing evidence suggests that these pathogenic proteins may spread to neighboring cells and induce the propagation of neurodegeneration. RESULTS: In this stu...

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Detalles Bibliográficos
Autores principales: Konno, Masatoshi, Hasegawa, Takafumi, Baba, Toru, Miura, Emiko, Sugeno, Naoto, Kikuchi, Akio, Fiesel, Fabienne C, Sasaki, Tsutomu, Aoki, Masashi, Itoyama, Yasuto, Takeda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479026/
https://www.ncbi.nlm.nih.gov/pubmed/22892036
http://dx.doi.org/10.1186/1750-1326-7-38

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