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Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels

Most investigations into cancer cell drug response are performed with cells cultured on flat (2D) tissue culture plastic. Emerging research has shown that the presence of a three-dimensional (3D) extracellular matrix (ECM) is critical for normal cell behavior including migration, adhesion, signaling...

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Detalles Bibliográficos
Autores principales:	Fallica, Brian, Maffei, Joseph S., Villa, Shaun, Makin, Guy, Zaman, Muhammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479126/ https://www.ncbi.nlm.nih.gov/pubmed/23110163 http://dx.doi.org/10.1371/journal.pone.0048024

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