The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes

The protein arginine methyltransferase 6 (PRMT6) is a coregulator of gene expression and executes its repressing as well as activating function by asymmetric dimethylation of histone H3 at R2 (H3 R2me2a). Given that elevated expression levels of PRMT6 have been reported in various cancer types, we e...

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Detalles Bibliográficos
Autores principales: Stein, Claudia, Riedl, Stefanie, Rüthnick, Diana, Nötzold, René Reiner, Bauer, Uta-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479209/
https://www.ncbi.nlm.nih.gov/pubmed/22904088
http://dx.doi.org/10.1093/nar/gks767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479209/
https://www.ncbi.nlm.nih.gov/pubmed/22904088
http://dx.doi.org/10.1093/nar/gks767

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