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Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2′-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) adducts that differ by a singl...

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Detalles Bibliográficos
Autores principales:	Mu, Hong, Kropachev, Konstantin, Wang, Lihua, Zhang, Lu, Kolbanovskiy, Alexander, Kolbanovskiy, Marina, E. Geacintov, Nicholas, Broyde, Suse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479214/ https://www.ncbi.nlm.nih.gov/pubmed/22904073 http://dx.doi.org/10.1093/nar/gks788

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