p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6

p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cance...

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Detalles Bibliográficos
Autores principales: Phalke, Sameer, Mzoughi, Slim, Bezzi, Marco, Jennifer, Nancy, Mok, Wei Chuen, Low, Diana H. P., Thike, Aye Aye, Kuznetsov, Vladimir A., Tan, Puay Hoon, Voorhoeve, P. Mathijs, Guccione, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479215/
https://www.ncbi.nlm.nih.gov/pubmed/22987071
http://dx.doi.org/10.1093/nar/gks858

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