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Immunologic Evaluation of Ofloxacin Hypersensitivity
Quinolone hypersensitivity, most of which is immediate type, is rare but has increased in recent years. The pathogenic mechanisms underlying immediate reactions are not defined clearly. This study was aimed to observe the clinical characteristics of immediate hypersensitivity to ofloxacin and to inv...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479232/ https://www.ncbi.nlm.nih.gov/pubmed/23115735 http://dx.doi.org/10.4168/aair.2012.4.6.367 |
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author | Nam, Young-Hee Kim, Jeong Eun Kim, Seung-Hyun Jin, Hyun Jung Hwang, Eui-Kyung Shin, Yoo Seob Ye, Young-Min Park, Hae-Sim |
author_facet | Nam, Young-Hee Kim, Jeong Eun Kim, Seung-Hyun Jin, Hyun Jung Hwang, Eui-Kyung Shin, Yoo Seob Ye, Young-Min Park, Hae-Sim |
author_sort | Nam, Young-Hee |
collection | PubMed |
description | Quinolone hypersensitivity, most of which is immediate type, is rare but has increased in recent years. The pathogenic mechanisms underlying immediate reactions are not defined clearly. This study was aimed to observe the clinical characteristics of immediate hypersensitivity to ofloxacin and to investigate the pathogenic mechanism with detection of serum specific IgE to ofloxacin using an enzyme-linked immunoasorbent assay (ELISA). We recruited 5 patients with immediate hypersensitivity reactions to ofloxacin (group I), and as control groups, 5 subjects with ciprofloxacin hypersensitivity (group II) and 20 healthy subjects with no history of drug allergy. Serum specific-IgE to ofloxacin-human serum albumin (HSA) conjugate was detectable in four group I subjects (80%) and three group II subjects (60%). The ELISA inhibition test showed significant inhibition with both ofloxacin-HSA conjugate and free ofloxacin in a dose-dependent manner. As to ciprofloxacin, significant inhibition was noted upon addition of free ciprofloxacin in one subject, while minimal inhibition was noted in the other. We confirmed that an IgE-mediated response is a major pathogenic mechanism of ofloxacin hypersensitivity. Cross reactivity between ofloxacin and ciprofloxacin was noted with individual difference. |
format | Online Article Text |
id | pubmed-3479232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-34792322012-11-01 Immunologic Evaluation of Ofloxacin Hypersensitivity Nam, Young-Hee Kim, Jeong Eun Kim, Seung-Hyun Jin, Hyun Jung Hwang, Eui-Kyung Shin, Yoo Seob Ye, Young-Min Park, Hae-Sim Allergy Asthma Immunol Res Brief Communication Quinolone hypersensitivity, most of which is immediate type, is rare but has increased in recent years. The pathogenic mechanisms underlying immediate reactions are not defined clearly. This study was aimed to observe the clinical characteristics of immediate hypersensitivity to ofloxacin and to investigate the pathogenic mechanism with detection of serum specific IgE to ofloxacin using an enzyme-linked immunoasorbent assay (ELISA). We recruited 5 patients with immediate hypersensitivity reactions to ofloxacin (group I), and as control groups, 5 subjects with ciprofloxacin hypersensitivity (group II) and 20 healthy subjects with no history of drug allergy. Serum specific-IgE to ofloxacin-human serum albumin (HSA) conjugate was detectable in four group I subjects (80%) and three group II subjects (60%). The ELISA inhibition test showed significant inhibition with both ofloxacin-HSA conjugate and free ofloxacin in a dose-dependent manner. As to ciprofloxacin, significant inhibition was noted upon addition of free ciprofloxacin in one subject, while minimal inhibition was noted in the other. We confirmed that an IgE-mediated response is a major pathogenic mechanism of ofloxacin hypersensitivity. Cross reactivity between ofloxacin and ciprofloxacin was noted with individual difference. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2012-11 2012-06-15 /pmc/articles/PMC3479232/ /pubmed/23115735 http://dx.doi.org/10.4168/aair.2012.4.6.367 Text en Copyright © 2012 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Nam, Young-Hee Kim, Jeong Eun Kim, Seung-Hyun Jin, Hyun Jung Hwang, Eui-Kyung Shin, Yoo Seob Ye, Young-Min Park, Hae-Sim Immunologic Evaluation of Ofloxacin Hypersensitivity |
title | Immunologic Evaluation of Ofloxacin Hypersensitivity |
title_full | Immunologic Evaluation of Ofloxacin Hypersensitivity |
title_fullStr | Immunologic Evaluation of Ofloxacin Hypersensitivity |
title_full_unstemmed | Immunologic Evaluation of Ofloxacin Hypersensitivity |
title_short | Immunologic Evaluation of Ofloxacin Hypersensitivity |
title_sort | immunologic evaluation of ofloxacin hypersensitivity |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479232/ https://www.ncbi.nlm.nih.gov/pubmed/23115735 http://dx.doi.org/10.4168/aair.2012.4.6.367 |
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