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Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis

BACKGROUND: IgA-dominant acute postinfectious glomerulonephritis (APIGN) is a recently recognized morphologic variant of APIGN, but its clinicopathologic features were not clearly characterized. We will present demographic, clinical and renal biopsy findings from seven patients with IgA-dominant API...

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Autores principales: Koo, Tai Yeon, Kim, Gheun-Ho, Park, Moon Hyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479780/
https://www.ncbi.nlm.nih.gov/pubmed/23109989
http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.105
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author Koo, Tai Yeon
Kim, Gheun-Ho
Park, Moon Hyang
author_facet Koo, Tai Yeon
Kim, Gheun-Ho
Park, Moon Hyang
author_sort Koo, Tai Yeon
collection PubMed
description BACKGROUND: IgA-dominant acute postinfectious glomerulonephritis (APIGN) is a recently recognized morphologic variant of APIGN, but its clinicopathologic features were not clearly characterized. We will present demographic, clinical and renal biopsy findings from seven patients with IgA-dominant APIGN with a literature review. METHODS: All renal biopsy specimens (n=1,119) processed by the Department of Pathology in Hanyang University Hospital from 2005 to 2009 were reviewed. Seven patients with IgA-dominant APIGN were identified, and their clinical data analyzed. RESULTS: All patients had renal failure, hematuria and proteinuria. One was diabetic, and none of the patients had previous renal diseases. Three had clinical infections at the time of presentation: 2 with methicillin-resistant Staphylococcus aureus and one with rickettsial infection. Light microscopically diffuse endocapillary proliferative and exudative glomerulonephritis was found in all cases. Immunofluorescence microscopy showed granular IgA deposits along peripheral capillary walls and in mesangium. Ultrastructurally, subepithelial 'humps' with mesangial deposits were noted. End-stage renal disease developed in two patients, chronic renal failure was stationary in two, and azotemia improved in three. CONCLUSIONS: Various infections including rickettsiosis preceded IgA-dominant APIGN in both diabetics and nondiabetics. Because the prognosis of IgA-dominant APIGN is poor, early diagnosis based on renal biopsy is required.
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spelling pubmed-34797802012-10-29 Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis Koo, Tai Yeon Kim, Gheun-Ho Park, Moon Hyang Korean J Pathol Original Article BACKGROUND: IgA-dominant acute postinfectious glomerulonephritis (APIGN) is a recently recognized morphologic variant of APIGN, but its clinicopathologic features were not clearly characterized. We will present demographic, clinical and renal biopsy findings from seven patients with IgA-dominant APIGN with a literature review. METHODS: All renal biopsy specimens (n=1,119) processed by the Department of Pathology in Hanyang University Hospital from 2005 to 2009 were reviewed. Seven patients with IgA-dominant APIGN were identified, and their clinical data analyzed. RESULTS: All patients had renal failure, hematuria and proteinuria. One was diabetic, and none of the patients had previous renal diseases. Three had clinical infections at the time of presentation: 2 with methicillin-resistant Staphylococcus aureus and one with rickettsial infection. Light microscopically diffuse endocapillary proliferative and exudative glomerulonephritis was found in all cases. Immunofluorescence microscopy showed granular IgA deposits along peripheral capillary walls and in mesangium. Ultrastructurally, subepithelial 'humps' with mesangial deposits were noted. End-stage renal disease developed in two patients, chronic renal failure was stationary in two, and azotemia improved in three. CONCLUSIONS: Various infections including rickettsiosis preceded IgA-dominant APIGN in both diabetics and nondiabetics. Because the prognosis of IgA-dominant APIGN is poor, early diagnosis based on renal biopsy is required. The Korean Society of Pathologists and The Korean Society for Cytopathology 2012-04 2012-04-25 /pmc/articles/PMC3479780/ /pubmed/23109989 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.105 Text en © 2012 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Koo, Tai Yeon
Kim, Gheun-Ho
Park, Moon Hyang
Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
title Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
title_full Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
title_fullStr Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
title_full_unstemmed Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
title_short Clinicopathologic Features of IgA-Dominant Postinfectious Glomerulonephritis
title_sort clinicopathologic features of iga-dominant postinfectious glomerulonephritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479780/
https://www.ncbi.nlm.nih.gov/pubmed/23109989
http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.105
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