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Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases
Villoglandular adenocarcinoma (VGA) is a rare subtype of cervical adenocarcinoma with a more favorable prognosis compared to conventional adenocarcinomas. Although the tumors are usually recognized on colposcopic examination due to the mainly exophytic growth pattern, they may be underdiagnosed as b...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and The Korean Society for Cytopathology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479784/ https://www.ncbi.nlm.nih.gov/pubmed/23110005 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.215 |
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author | Choi, Younghwa Kim, Haeryoung Choi, Haiyoung Hwang, Daehyun Choe, Gheeyoung Chung, Jin-Haeng Park, So Yeon Lee, Hye Seung Paik, Jin Ho Park, Hyo Jin |
author_facet | Choi, Younghwa Kim, Haeryoung Choi, Haiyoung Hwang, Daehyun Choe, Gheeyoung Chung, Jin-Haeng Park, So Yeon Lee, Hye Seung Paik, Jin Ho Park, Hyo Jin |
author_sort | Choi, Younghwa |
collection | PubMed |
description | Villoglandular adenocarcinoma (VGA) is a rare subtype of cervical adenocarcinoma with a more favorable prognosis compared to conventional adenocarcinomas. Although the tumors are usually recognized on colposcopic examination due to the mainly exophytic growth pattern, they may be underdiagnosed as benign lesions by cytology because of their minimal cytologic atypia. We report the liquid-based cytology (LBC) findings of three histologically confirmed VGAs which we have recently identified. They were characterized by hypercellular smears on low-power examination with smooth-bordered three-dimensional papillary fragments. The nuclei were relatively uniform with irregular nuclear membranes. Nucleoli were small but distinct and macronucleoli were also seen. The abnormal architectural patterns such as papillary structures and nuclear overlapping and nuclear hyperchromasia are important clues to the diagnosis of VGA. In addition, nuclear membrane irregularity and prominent nucleoli can be recognized on LBC specimens, further facilitating its diagnosis. |
format | Online Article Text |
id | pubmed-3479784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society of Pathologists and The Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-34797842012-10-29 Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases Choi, Younghwa Kim, Haeryoung Choi, Haiyoung Hwang, Daehyun Choe, Gheeyoung Chung, Jin-Haeng Park, So Yeon Lee, Hye Seung Paik, Jin Ho Park, Hyo Jin Korean J Pathol Case Report Villoglandular adenocarcinoma (VGA) is a rare subtype of cervical adenocarcinoma with a more favorable prognosis compared to conventional adenocarcinomas. Although the tumors are usually recognized on colposcopic examination due to the mainly exophytic growth pattern, they may be underdiagnosed as benign lesions by cytology because of their minimal cytologic atypia. We report the liquid-based cytology (LBC) findings of three histologically confirmed VGAs which we have recently identified. They were characterized by hypercellular smears on low-power examination with smooth-bordered three-dimensional papillary fragments. The nuclei were relatively uniform with irregular nuclear membranes. Nucleoli were small but distinct and macronucleoli were also seen. The abnormal architectural patterns such as papillary structures and nuclear overlapping and nuclear hyperchromasia are important clues to the diagnosis of VGA. In addition, nuclear membrane irregularity and prominent nucleoli can be recognized on LBC specimens, further facilitating its diagnosis. The Korean Society of Pathologists and The Korean Society for Cytopathology 2012-04 2012-04-25 /pmc/articles/PMC3479784/ /pubmed/23110005 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.215 Text en © 2012 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Choi, Younghwa Kim, Haeryoung Choi, Haiyoung Hwang, Daehyun Choe, Gheeyoung Chung, Jin-Haeng Park, So Yeon Lee, Hye Seung Paik, Jin Ho Park, Hyo Jin Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases |
title | Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases |
title_full | Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases |
title_fullStr | Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases |
title_full_unstemmed | Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases |
title_short | Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases |
title_sort | liquid-based cytology of villoglandular adenocarcinoma of the cervix: a report of 3 cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479784/ https://www.ncbi.nlm.nih.gov/pubmed/23110005 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.215 |
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