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Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report

Clear cell adenocarcinoma of the urethra is a rare disease entity with an uncertain histogenesis. Here, we present a case of primary clear cell adenocarcinoma of the female urethra with its cytological findings. A 54-year-old woman presented with a painless gross hematuria lasting 3 months. On vagin...

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Autores principales: Han, Jee-Young, Kim, Kyu-Ho, Kim, Lucia, Choi, Suk-Jin, Park, In-Suh, Kim, Joon-Mee, Chu, Young-Chae, Yoon, Sang-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and The Korean Society for Cytopathology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479785/
https://www.ncbi.nlm.nih.gov/pubmed/23110004
http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.210
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author Han, Jee-Young
Kim, Kyu-Ho
Kim, Lucia
Choi, Suk-Jin
Park, In-Suh
Kim, Joon-Mee
Chu, Young-Chae
Yoon, Sang-Min
author_facet Han, Jee-Young
Kim, Kyu-Ho
Kim, Lucia
Choi, Suk-Jin
Park, In-Suh
Kim, Joon-Mee
Chu, Young-Chae
Yoon, Sang-Min
author_sort Han, Jee-Young
collection PubMed
description Clear cell adenocarcinoma of the urethra is a rare disease entity with an uncertain histogenesis. Here, we present a case of primary clear cell adenocarcinoma of the female urethra with its cytological findings. A 54-year-old woman presented with a painless gross hematuria lasting 3 months. On vaginal sonography, there was a sausage-like, elongated mass in the urethra, measuring 3.8×4.3 cm. The voided urine cytology revealed small clusters of rounded or papillary cells. The necrotic debris and inflammatory cells were present within some clusters of tumor cells. These tumor cells were enlarged and had abundant clear or granular cytoplasm with cytoplasmic vacuoles. The nucleus was granular and contained vesicular chromatin with prominent nucleoli. The hobnail cells and hyaline globules were also present as in a histologic section. The histologic findings were compatible with clear cell adenocarcinoma. The tumor showed distinctive cytological features. Cytologically, however, it is necessary to make a differential diagnosis from other adenocarcinoma or high-grade urothelial carcinoma.
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spelling pubmed-34797852012-10-29 Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report Han, Jee-Young Kim, Kyu-Ho Kim, Lucia Choi, Suk-Jin Park, In-Suh Kim, Joon-Mee Chu, Young-Chae Yoon, Sang-Min Korean J Pathol Case Report Clear cell adenocarcinoma of the urethra is a rare disease entity with an uncertain histogenesis. Here, we present a case of primary clear cell adenocarcinoma of the female urethra with its cytological findings. A 54-year-old woman presented with a painless gross hematuria lasting 3 months. On vaginal sonography, there was a sausage-like, elongated mass in the urethra, measuring 3.8×4.3 cm. The voided urine cytology revealed small clusters of rounded or papillary cells. The necrotic debris and inflammatory cells were present within some clusters of tumor cells. These tumor cells were enlarged and had abundant clear or granular cytoplasm with cytoplasmic vacuoles. The nucleus was granular and contained vesicular chromatin with prominent nucleoli. The hobnail cells and hyaline globules were also present as in a histologic section. The histologic findings were compatible with clear cell adenocarcinoma. The tumor showed distinctive cytological features. Cytologically, however, it is necessary to make a differential diagnosis from other adenocarcinoma or high-grade urothelial carcinoma. The Korean Society of Pathologists and The Korean Society for Cytopathology 2012-04 2012-04-25 /pmc/articles/PMC3479785/ /pubmed/23110004 http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.210 Text en © 2012 The Korean Society of Pathologists/The Korean Society for Cytopathology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Han, Jee-Young
Kim, Kyu-Ho
Kim, Lucia
Choi, Suk-Jin
Park, In-Suh
Kim, Joon-Mee
Chu, Young-Chae
Yoon, Sang-Min
Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
title Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
title_full Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
title_fullStr Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
title_full_unstemmed Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
title_short Cytologic Findings of Clear Cell Adenocarcinoma of the Urethra: A Case Report
title_sort cytologic findings of clear cell adenocarcinoma of the urethra: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479785/
https://www.ncbi.nlm.nih.gov/pubmed/23110004
http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.210
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