Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the rol...

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Autores principales: Stowell, Sean R., Winkler, Anne M., Maier, Cheryl L., Arthur, C. Maridith, Smith, Nicole H., Girard-Pierce, Kathryn R., Cummings, Richard D., Zimring, James C., Hendrickson, Jeanne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479954/
https://www.ncbi.nlm.nih.gov/pubmed/23118779
http://dx.doi.org/10.1155/2012/307093
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author Stowell, Sean R.
Winkler, Anne M.
Maier, Cheryl L.
Arthur, C. Maridith
Smith, Nicole H.
Girard-Pierce, Kathryn R.
Cummings, Richard D.
Zimring, James C.
Hendrickson, Jeanne E.
author_facet Stowell, Sean R.
Winkler, Anne M.
Maier, Cheryl L.
Arthur, C. Maridith
Smith, Nicole H.
Girard-Pierce, Kathryn R.
Cummings, Richard D.
Zimring, James C.
Hendrickson, Jeanne E.
author_sort Stowell, Sean R.
collection PubMed
description Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.
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spelling pubmed-34799542012-11-01 Initiation and Regulation of Complement during Hemolytic Transfusion Reactions Stowell, Sean R. Winkler, Anne M. Maier, Cheryl L. Arthur, C. Maridith Smith, Nicole H. Girard-Pierce, Kathryn R. Cummings, Richard D. Zimring, James C. Hendrickson, Jeanne E. Clin Dev Immunol Review Article Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions. Hindawi Publishing Corporation 2012 2012-10-16 /pmc/articles/PMC3479954/ /pubmed/23118779 http://dx.doi.org/10.1155/2012/307093 Text en Copyright © 2012 Sean R. Stowell et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Stowell, Sean R.
Winkler, Anne M.
Maier, Cheryl L.
Arthur, C. Maridith
Smith, Nicole H.
Girard-Pierce, Kathryn R.
Cummings, Richard D.
Zimring, James C.
Hendrickson, Jeanne E.
Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
title Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
title_full Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
title_fullStr Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
title_full_unstemmed Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
title_short Initiation and Regulation of Complement during Hemolytic Transfusion Reactions
title_sort initiation and regulation of complement during hemolytic transfusion reactions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479954/
https://www.ncbi.nlm.nih.gov/pubmed/23118779
http://dx.doi.org/10.1155/2012/307093
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