Cargando…
Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience
Objective. The goal of the study was to analyse the results of 85 cases of second-look laparotomy (SLL) and explore the influence of this procedure on survival. Patients and Methods. We reviewed retrospectively 85 cases of SLL collected and treated in our institute between 1994 and 2003. Results. Co...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479993/ https://www.ncbi.nlm.nih.gov/pubmed/23119177 http://dx.doi.org/10.5402/2012/849518 |
_version_ | 1782247492659707904 |
---|---|
author | Damak, Tarak Chargui, Riadh Ben Hassouna, Jamel Hechiche, Monia Rahal, Khaled |
author_facet | Damak, Tarak Chargui, Riadh Ben Hassouna, Jamel Hechiche, Monia Rahal, Khaled |
author_sort | Damak, Tarak |
collection | PubMed |
description | Objective. The goal of the study was to analyse the results of 85 cases of second-look laparotomy (SLL) and explore the influence of this procedure on survival. Patients and Methods. We reviewed retrospectively 85 cases of SLL collected and treated in our institute between 1994 and 2003. Results. Complete pathologic response (CPR) was 25.8%, microscopic disease (Rmicro) was 38.8%, and macroscopic disease (Rmacro) was 35.4%. In patients with negative SLL results, disease recurrence was diagnosed in 41%. The 3- and 5-year overall survival rates for the entire population were 91% and 87%, respectively. The 3- and 5-year disease-free survivals were, respectively, 76.3% and 58.5% in negative SLL versus 55.7% and 16% in positive SLL. The difference between the group of patients with complete response (76%) and the patients with residual microscopic disease (72%) was not significant. The tumoral residuum after initial surgery was the only prognostic factor influencing significantly the disease-free survival. On Cox regression model analysis, only initial tumoral residuum (P = 0.04) and tumoral residuum after SLL (P = 0.02) were independent prognostic factors for survival. Conclusions. The most important advantage of SLL is the early detection of recurrence and thus the early administration of consolidation treatment resulting in a better prognosis. |
format | Online Article Text |
id | pubmed-3479993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-34799932012-11-01 Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience Damak, Tarak Chargui, Riadh Ben Hassouna, Jamel Hechiche, Monia Rahal, Khaled ISRN Obstet Gynecol Research Article Objective. The goal of the study was to analyse the results of 85 cases of second-look laparotomy (SLL) and explore the influence of this procedure on survival. Patients and Methods. We reviewed retrospectively 85 cases of SLL collected and treated in our institute between 1994 and 2003. Results. Complete pathologic response (CPR) was 25.8%, microscopic disease (Rmicro) was 38.8%, and macroscopic disease (Rmacro) was 35.4%. In patients with negative SLL results, disease recurrence was diagnosed in 41%. The 3- and 5-year overall survival rates for the entire population were 91% and 87%, respectively. The 3- and 5-year disease-free survivals were, respectively, 76.3% and 58.5% in negative SLL versus 55.7% and 16% in positive SLL. The difference between the group of patients with complete response (76%) and the patients with residual microscopic disease (72%) was not significant. The tumoral residuum after initial surgery was the only prognostic factor influencing significantly the disease-free survival. On Cox regression model analysis, only initial tumoral residuum (P = 0.04) and tumoral residuum after SLL (P = 0.02) were independent prognostic factors for survival. Conclusions. The most important advantage of SLL is the early detection of recurrence and thus the early administration of consolidation treatment resulting in a better prognosis. International Scholarly Research Network 2012-10-16 /pmc/articles/PMC3479993/ /pubmed/23119177 http://dx.doi.org/10.5402/2012/849518 Text en Copyright © 2012 Tarak Damak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Damak, Tarak Chargui, Riadh Ben Hassouna, Jamel Hechiche, Monia Rahal, Khaled Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience |
title | Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience |
title_full | Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience |
title_fullStr | Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience |
title_full_unstemmed | Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience |
title_short | Results of Second-Look Laparotomy in Advanced Ovarian Cancer: One Single Center Experience |
title_sort | results of second-look laparotomy in advanced ovarian cancer: one single center experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479993/ https://www.ncbi.nlm.nih.gov/pubmed/23119177 http://dx.doi.org/10.5402/2012/849518 |
work_keys_str_mv | AT damaktarak resultsofsecondlooklaparotomyinadvancedovariancanceronesinglecenterexperience AT charguiriadh resultsofsecondlooklaparotomyinadvancedovariancanceronesinglecenterexperience AT benhassounajamel resultsofsecondlooklaparotomyinadvancedovariancanceronesinglecenterexperience AT hechichemonia resultsofsecondlooklaparotomyinadvancedovariancanceronesinglecenterexperience AT rahalkhaled resultsofsecondlooklaparotomyinadvancedovariancanceronesinglecenterexperience |