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mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch

Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid neoplasia and represents the end stage of thyroid tumor progression. No effective treatment exists so far. ATC frequently derive from papillary thyroid carcinomas (PTC), which have a good prognosis. In this study, we analyzed the...

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Autores principales: Hébrant, Aline, Dom, Geneviève, Dewaele, Michael, Andry, Guy, Trésallet, Christophe, Leteurtre, Emmanuelle, Dumont, Jacques E., Maenhaut, Carine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480355/
https://www.ncbi.nlm.nih.gov/pubmed/23115614
http://dx.doi.org/10.1371/journal.pone.0037807
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author Hébrant, Aline
Dom, Geneviève
Dewaele, Michael
Andry, Guy
Trésallet, Christophe
Leteurtre, Emmanuelle
Dumont, Jacques E.
Maenhaut, Carine
author_facet Hébrant, Aline
Dom, Geneviève
Dewaele, Michael
Andry, Guy
Trésallet, Christophe
Leteurtre, Emmanuelle
Dumont, Jacques E.
Maenhaut, Carine
author_sort Hébrant, Aline
collection PubMed
description Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid neoplasia and represents the end stage of thyroid tumor progression. No effective treatment exists so far. ATC frequently derive from papillary thyroid carcinomas (PTC), which have a good prognosis. In this study, we analyzed the mRNA expression profiles of 59 thyroid tumors (11 ATC and 48 PTC) by microarrays. ATC and PTC showed largely overlapping mRNA expression profiles with most genes regulated in all ATC being also regulated in several PTC. 43% of the probes regulated in all the PTC are similarly regulated in all ATC. Many genes modulations observed in PTC are amplified in ATC. This illustrates the fact that ATC mostly derived from PTC. A molecular signature of aggressiveness composed of 9 genes clearly separates the two tumors. Moreover, this study demonstrates gene regulations corresponding to the ATC or PTC phenotypes like inflammatory reaction, epithelial to mesenchymal transition (EMT) and invasion, high proliferation rate, dedifferentiation, calcification and fibrosis processes, high glucose metabolism and glycolysis, lactate generation and chemoresistance. The main qualitative differences between the two tumor types bear on the much stronger EMT, dedifferentiation and glycolytic phenotypes showed by the ATC.
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spelling pubmed-34803552012-10-31 mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch Hébrant, Aline Dom, Geneviève Dewaele, Michael Andry, Guy Trésallet, Christophe Leteurtre, Emmanuelle Dumont, Jacques E. Maenhaut, Carine PLoS One Research Article Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid neoplasia and represents the end stage of thyroid tumor progression. No effective treatment exists so far. ATC frequently derive from papillary thyroid carcinomas (PTC), which have a good prognosis. In this study, we analyzed the mRNA expression profiles of 59 thyroid tumors (11 ATC and 48 PTC) by microarrays. ATC and PTC showed largely overlapping mRNA expression profiles with most genes regulated in all ATC being also regulated in several PTC. 43% of the probes regulated in all the PTC are similarly regulated in all ATC. Many genes modulations observed in PTC are amplified in ATC. This illustrates the fact that ATC mostly derived from PTC. A molecular signature of aggressiveness composed of 9 genes clearly separates the two tumors. Moreover, this study demonstrates gene regulations corresponding to the ATC or PTC phenotypes like inflammatory reaction, epithelial to mesenchymal transition (EMT) and invasion, high proliferation rate, dedifferentiation, calcification and fibrosis processes, high glucose metabolism and glycolysis, lactate generation and chemoresistance. The main qualitative differences between the two tumor types bear on the much stronger EMT, dedifferentiation and glycolytic phenotypes showed by the ATC. Public Library of Science 2012-10-24 /pmc/articles/PMC3480355/ /pubmed/23115614 http://dx.doi.org/10.1371/journal.pone.0037807 Text en © 2012 Hébrant et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hébrant, Aline
Dom, Geneviève
Dewaele, Michael
Andry, Guy
Trésallet, Christophe
Leteurtre, Emmanuelle
Dumont, Jacques E.
Maenhaut, Carine
mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
title mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
title_full mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
title_fullStr mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
title_full_unstemmed mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
title_short mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
title_sort mrna expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480355/
https://www.ncbi.nlm.nih.gov/pubmed/23115614
http://dx.doi.org/10.1371/journal.pone.0037807
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