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Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)

Skeletal muscle resistance to the key metabolic hormones, leptin and insulin, is an early defect in obesity. Suppressor of cytokine signaling 3 (SOCS3) is a major negative regulator of both leptin and insulin signaling, thereby implicating SOCS3 in the pathogenesis of obesity and associated metaboli...

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Detalles Bibliográficos
Autores principales:	Yang, Zhenggang, Hulver, Matthew, McMillan, Ryan P., Cai, Lingzhi, Kershaw, Erin E., Yu, Liqing, Xue, Bingzhong, Shi, Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480378/ https://www.ncbi.nlm.nih.gov/pubmed/23115649 http://dx.doi.org/10.1371/journal.pone.0047493

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