Cargando…

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

Recent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n−6) arachidonic acid (AA). Although the metabolic pathways (COX, LOX, and P450) that generate these n−6 AA eicosanoids have bee...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Chengwei, Qu, Xiying, Wan, Jianbo, Rong, Rong, Huang, Lili, Cai, Chun, Zhou, Keyuan, Gu, Yan, Qian, Steven Y., Kang, Jing X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480421/ https://www.ncbi.nlm.nih.gov/pubmed/23112819 http://dx.doi.org/10.1371/journal.pone.0047567

Ejemplares similares

Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells
por: He, Chengwei, et al.
Publicado: (2012)

Delta-5-desaturase: A novel therapeutic target for cancer management
por: Pang, Lizhi, et al.
Publicado: (2021)

Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro
por: Solakivi, Tiina, et al.
Publicado: (2013)

Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo
por: Wang, Jie, et al.
Publicado: (2018)

Improved γ-linolenic acid production in Mucor circinelloides by homologous overexpressing of delta-12 and delta-6 desaturases
por: Zhang, Yao, et al.
Publicado: (2017)

Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction
por: Martorelli Di Genova, Bruno, et al.
Publicado: (2019)

Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection
por: Chiang, Keng-Yu, et al.
Publicado: (2020)

Application of a delta-6 desaturase with α-linolenic acid preference on eicosapentaenoic acid production in Mortierella alpina
por: Shi, Haisu, et al.
Publicado: (2016)

Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression
por: Xu, Yi, et al.
Publicado: (2018)

Transgenic expression of delta-6 and delta-15 fatty acid desaturases enhances omega-3 polyunsaturated fatty acid accumulation in Synechocystis sp. PCC6803
por: Chen, Gao, et al.
Publicado: (2014)

Production of eicosapentaenoic acid by application of a delta-6 desaturase with the highest ALA catalytic activity in algae
por: Shi, Haisu, et al.
Publicado: (2018)

Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells
por: Yang, Xiaoyu, et al.
Publicado: (2017)

Delta-6-desaturase (FADS2) inhibition and omega-3 fatty acids in skeletal muscle protein turnover
por: Brown, Katie M., et al.
Publicado: (2019)

Association of Delta-6-Desaturase Expression with Aggressiveness of Cancer, Diabetes Mellitus, and Multiple Sclerosis: A Narrative Review
por: Arshad, Zhila, et al.
Publicado: (2019)

Molecular mechanism of interaction between fatty acid delta 6 desaturase and acyl-CoA by computational prediction
por: Cui, Jie, et al.
Publicado: (2022)

Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase
por: Xu, Yi, et al.
Publicado: (2018)

Delta-9 fatty acid desaturase mutants display increased body size
por: Clark, James F., et al.
Publicado: (2018)

The yin and yang of 15-lipoxygenase-1 and delta-desaturases: Dietary omega-6 linoleic acid metabolic pathway in prostate
por: Kelavkar, Uddhav, et al.
Publicado: (2006)

Delta-6 desaturase (Fads2) deficiency alters triacylglycerol/fatty acid cycling in murine white adipose tissue
por: Wang, Chenxuan, et al.
Publicado: (2023)

The sphingolipid biosynthetic enzyme Sphingolipid delta8 desaturase is important for chilling resistance of tomato
por: Zhou, Ying, et al.
Publicado: (2016)

Comparative transcriptome analysis reveals ectopic delta-5 and delta-6 desaturases enhance protective gene expression upon Vibrio vulnificus challenge in Tilapia (Oreochromis niloticus)
por: Tu, Pin-Yang, et al.
Publicado: (2021)

Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA
por: Yang, Xiaoyu, et al.
Publicado: (2018)

Fatty acid profiles and Delta9 desaturase (stearoyl-CoA desaturase; SCD 1) expression in adipose tissue surrounding benign and malignant breast tumors
por: Sefidabi, Reyhaneh, et al.
Publicado: (2023)

Homologous and Heterologous Expression of Delta(12)-Desaturase in Mucor circinelloides Enhanced the Production of Linolenic Acid
por: Yang, Junhuan, et al.
Publicado: (2022)

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse
por: Monteiro, Jessica, et al.
Publicado: (2012)

NSCLC Cells Resistance to PI3K/mTOR Inhibitors Is Mediated by Delta-6 Fatty Acid Desaturase (FADS2)
por: Colombo, Marika, et al.
Publicado: (2022)

A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice
por: Yashiro, Hiroaki, et al.
Publicado: (2016)

Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome
por: Arai, Ken, et al.
Publicado: (2020)

EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation
por: Pang, Lizhi, et al.
Publicado: (2020)

Erratum to “Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells” [Redox Biol. 11 (2017) 653–662]
por: Yang, Xiaoyu, et al.
Publicado: (2017)

Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study
por: Abdelmagid, Salma A, et al.
Publicado: (2015)

Relationship between Body Mass Index, C-Peptide, and Delta-5-Desaturase Enzyme Activity Estimates in Adult Males
por: Pickens, C. Austin, et al.
Publicado: (2016)

Effects of Temperature and Salt Stress on the Expression of delta-12 Fatty Acid Desaturase Genes and Fatty Acid Compositions in Safflower
por: Li, Dandan, et al.
Publicado: (2023)

Analysis of Delta(9) fatty acid desaturase gene family and their role in oleic acid accumulation in Carya cathayensis kernel
por: Si, Xiaolin, et al.
Publicado: (2023)

Identification and functional analysis of the genes encoding Δ(6)-desaturase from Ribes nigrum†
por: Song, Li-Ying, et al.
Publicado: (2010)

Identification and Functional Analysis of Delta-9 Desaturase, a Key Enzyme in PUFA Synthesis, Isolated from the Oleaginous Diatom Fistulifera
por: Muto, Masaki, et al.
Publicado: (2013)

Saturated Fatty Acid Intake Is Associated With Increased Inflammation, Conversion of Kynurenine to Tryptophan, and Delta-9 Desaturase Activity in Healthy Humans
por: Berg, Jade, et al.
Publicado: (2020)

Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism
por: Xu, Yi, et al.
Publicado: (2018)

Expression and Purification of Integral Membrane Fatty Acid Desaturases
por: Chen, Haiqin, et al.
Publicado: (2013)

Low temperature and light regulate delta 12 fatty acid desaturases (FAD2) at a transcriptional level in cotton (Gossypium hirsutum)
por: Kargiotidou, Anastasia, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_uptmbne3ees4rjhak4ou8msn0e