Carnitine Deficiency in OCTN2(−/−) Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

We have investigated the gross, microscopic and molecular effects of carnitine deficiency in the neonatal gut using a mouse model with a loss-of-function mutation in the OCTN2 (SLC22A5) carnitine transporter. The tissue carnitine content of neonatal homozygous (OCTN2(−/−)) mouse small intestine was...

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Detalles Bibliográficos
Autores principales: Sonne, Srinivas, Shekhawat, Prem S., Matern, Dietrich, Ganapathy, Vadivel, Ignatowicz, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480427/
https://www.ncbi.nlm.nih.gov/pubmed/23112839
http://dx.doi.org/10.1371/journal.pone.0047729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480427/
https://www.ncbi.nlm.nih.gov/pubmed/23112839
http://dx.doi.org/10.1371/journal.pone.0047729

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