Cargando…
Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes?
Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480428/ https://www.ncbi.nlm.nih.gov/pubmed/23112853 http://dx.doi.org/10.1371/journal.pone.0047830 |
_version_ | 1782247557952438272 |
---|---|
author | Miller, Ashley M. Purves, David McConnachie, Alex Asquith, Darren L. Batty, G. David Burns, Harry Cavanagh, Jonathan Ford, Ian McLean, Jennifer S. Packard, Chris J. Shiels, Paul G. Turner, Helen Velupillai, Yoga N. Deans, Kevin A. Welsh, Paul McInnes, Iain B. Sattar, Naveed |
author_facet | Miller, Ashley M. Purves, David McConnachie, Alex Asquith, Darren L. Batty, G. David Burns, Harry Cavanagh, Jonathan Ford, Ian McLean, Jennifer S. Packard, Chris J. Shiels, Paul G. Turner, Helen Velupillai, Yoga N. Deans, Kevin A. Welsh, Paul McInnes, Iain B. Sattar, Naveed |
author_sort | Miller, Ashley M. |
collection | PubMed |
description | Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk in man is completely lacking. We sought to address this gap via a comprehensive analysis of risk factor and vascular correlates of sST2 in a cross-sectional study (pSoBid). We measured sST2 in plasma in 639 subjects and comprehensively related it to cardiovascular and diabetes risk factors and imaged atherosclerosis measures. Circulating sST2 levels increased with age, were lower in women and in highest earners. After adjusting for age and gender, sST2 levels associated strongly with markers of diabetes, including triglycerides [effect estimate (EE) per 1 standard deviation increase in sST2∶1.05 [95%CI 1.01,1.10]), liver function (alanine aminotransaminase [ALT] and γ-glutamyl transferase [GGT]: EE 1.05 [1.01,1.09] and 1.13 [1.07,1.19] respectively), glucose (1.02 [1.00,1.03]) and sICAM-1 (1.05 [1.02,1.07]). However, sST2 levels were not related to smoking, cholesterol, blood pressure, or atheroma (carotid intima media thickness, plaque presence). These results suggest that sST2 levels, in individuals largely without vascular disease, are related principally to markers associated with diabetes and ectopic fat and add support for a role of sST2 in diabetes. Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes. |
format | Online Article Text |
id | pubmed-3480428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34804282012-10-30 Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? Miller, Ashley M. Purves, David McConnachie, Alex Asquith, Darren L. Batty, G. David Burns, Harry Cavanagh, Jonathan Ford, Ian McLean, Jennifer S. Packard, Chris J. Shiels, Paul G. Turner, Helen Velupillai, Yoga N. Deans, Kevin A. Welsh, Paul McInnes, Iain B. Sattar, Naveed PLoS One Research Article Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk in man is completely lacking. We sought to address this gap via a comprehensive analysis of risk factor and vascular correlates of sST2 in a cross-sectional study (pSoBid). We measured sST2 in plasma in 639 subjects and comprehensively related it to cardiovascular and diabetes risk factors and imaged atherosclerosis measures. Circulating sST2 levels increased with age, were lower in women and in highest earners. After adjusting for age and gender, sST2 levels associated strongly with markers of diabetes, including triglycerides [effect estimate (EE) per 1 standard deviation increase in sST2∶1.05 [95%CI 1.01,1.10]), liver function (alanine aminotransaminase [ALT] and γ-glutamyl transferase [GGT]: EE 1.05 [1.01,1.09] and 1.13 [1.07,1.19] respectively), glucose (1.02 [1.00,1.03]) and sICAM-1 (1.05 [1.02,1.07]). However, sST2 levels were not related to smoking, cholesterol, blood pressure, or atheroma (carotid intima media thickness, plaque presence). These results suggest that sST2 levels, in individuals largely without vascular disease, are related principally to markers associated with diabetes and ectopic fat and add support for a role of sST2 in diabetes. Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes. Public Library of Science 2012-10-24 /pmc/articles/PMC3480428/ /pubmed/23112853 http://dx.doi.org/10.1371/journal.pone.0047830 Text en © 2012 Miller et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Miller, Ashley M. Purves, David McConnachie, Alex Asquith, Darren L. Batty, G. David Burns, Harry Cavanagh, Jonathan Ford, Ian McLean, Jennifer S. Packard, Chris J. Shiels, Paul G. Turner, Helen Velupillai, Yoga N. Deans, Kevin A. Welsh, Paul McInnes, Iain B. Sattar, Naveed Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? |
title | Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? |
title_full | Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? |
title_fullStr | Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? |
title_full_unstemmed | Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? |
title_short | Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? |
title_sort | soluble st2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480428/ https://www.ncbi.nlm.nih.gov/pubmed/23112853 http://dx.doi.org/10.1371/journal.pone.0047830 |
work_keys_str_mv | AT millerashleym solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT purvesdavid solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT mcconnachiealex solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT asquithdarrenl solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT battygdavid solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT burnsharry solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT cavanaghjonathan solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT fordian solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT mcleanjennifers solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT packardchrisj solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT shielspaulg solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT turnerhelen solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT velupillaiyogan solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT deanskevina solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT welshpaul solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT mcinnesiainb solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes AT sattarnaveed solublest2associateswithdiabetesbutnotestablishedcardiovascularriskfactorsanewinflammatorypathwayofrelevancetodiabetes |