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Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

High-fat diet (HFD) induced obesity and concomitant development of insulin resistance (IR) and type 2 diabetes mellitus have been linked to mitochondrial dysfunction. However, it is not clear whether mitochondrial dysfunction is a direct effect of a HFD, or if mitochondrial function is reduced with...

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Detalles Bibliográficos
Autores principales:	Sadler, Natalie C., Angel, Thomas E., Lewis, Michael P., Pederson, LeeAnna M., Chauvigné-Hines, Lacie M., Wiedner, Susan D., Zink, Erika M., Smith, Richard D., Wright, Aaron T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480472/ https://www.ncbi.nlm.nih.gov/pubmed/23110155 http://dx.doi.org/10.1371/journal.pone.0047996

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