PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent

Poly(ADP-ribose) polymerase-1 (PARP-1) is widely involved in cell death responses. Depending on the degree of injury and on cell type, PARP activation may lead to autophagy, apoptosis or necrosis. In HEK293 cells exposed to the alkylating agent N-methyl-N’-nitro-N’-nitrosoguanine (MNNG), we show tha...

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Detalles Bibliográficos
Autores principales: Éthier, Chantal, Tardif, Maxime, Arul, Laura, Poirier, Guy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480502/
https://www.ncbi.nlm.nih.gov/pubmed/23110147
http://dx.doi.org/10.1371/journal.pone.0047978

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