The CD39-Adenosinergic Axis in the Pathogenesis of Immune and Nonimmune Diabetes

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosiner...

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Detalles Bibliográficos
Autores principales: Chia, Joanne S. J., McRae, Jennifer L., Cowan, Peter J., Dwyer, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480695/
https://www.ncbi.nlm.nih.gov/pubmed/23118504
http://dx.doi.org/10.1155/2012/320495
Descripción
Sumario:Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes. Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar. In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.

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