Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Here we report the discovery of a highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein. Using a chemical lead, identified by fragment screening and structure-guided design, we demonstrate that this site has...

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Detalles Bibliográficos
Autores principales: Saalau-Bethell, Susanne M., Woodhead, Andrew J., Chessari, Gianni, Carr, Maria G., Coyle, Joseph, Graham, Brent, Hiscock, Steven D., Murray, Christopher W., Pathuri, Puja, Rich, Sharna J., Richardson, Caroline J., Williams, Pamela A., Jhoti, Harren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480716/
https://www.ncbi.nlm.nih.gov/pubmed/23023261
http://dx.doi.org/10.1038/nchembio.1081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480716/
https://www.ncbi.nlm.nih.gov/pubmed/23023261
http://dx.doi.org/10.1038/nchembio.1081

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