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Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study

This paper describes a comparative study on the performances of ethosomes and solid lipid nanoparticle as delivery systems for acyclovir. Ethosomes were spontaneously produced by dissolution of phosphatidylcholine and acyclovir in ethanol followed by addition of an aqueous buffer while solid lipid n...

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Autores principales: Cortesi, Rita, Ravani, Laura, Menegatti, Enea, Drechsler, M., Esposito, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480758/
https://www.ncbi.nlm.nih.gov/pubmed/23112407
http://dx.doi.org/10.4103/0250-474X.100253
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author Cortesi, Rita
Ravani, Laura
Menegatti, Enea
Drechsler, M.
Esposito, Elisabetta
author_facet Cortesi, Rita
Ravani, Laura
Menegatti, Enea
Drechsler, M.
Esposito, Elisabetta
author_sort Cortesi, Rita
collection PubMed
description This paper describes a comparative study on the performances of ethosomes and solid lipid nanoparticle as delivery systems for acyclovir. Ethosomes were spontaneously produced by dissolution of phosphatidylcholine and acyclovir in ethanol followed by addition of an aqueous buffer while solid lipid nanoparticle were produced by homogenization and ultrasonication. Both colloidal systems were morphologically characterized by cryo-transmission electron microscopy. The encapsulation efficiency was 94.2±2.8% for ethosomes and 53.2±0.2% for solid lipid nanoparticle. Concerning Z potential, both formulations are close to neutrality. The diffusion coefficients of the drug from ethosomes and solid lipid nanoparticle, determined by a Franz cell method, were 9.4 and 1.2-fold lower as compared to the free acyclovir in solution, thus evidencing the ability of both colloidal systems in enhancing the diffusion of the drug. The antiviral activity against HSV-1 of both systems was tested by plaque reduction assay in monolayer cultures of Vero cells. Data showed that no significant differences in the antiviral activity were observed by acyclovir in the free or loaded forms. Taken together these results, colloidal systems could be interesting to mediate the penetration of acyclovir within Vero cells.
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spelling pubmed-34807582012-10-30 Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study Cortesi, Rita Ravani, Laura Menegatti, Enea Drechsler, M. Esposito, Elisabetta Indian J Pharm Sci Short Communications This paper describes a comparative study on the performances of ethosomes and solid lipid nanoparticle as delivery systems for acyclovir. Ethosomes were spontaneously produced by dissolution of phosphatidylcholine and acyclovir in ethanol followed by addition of an aqueous buffer while solid lipid nanoparticle were produced by homogenization and ultrasonication. Both colloidal systems were morphologically characterized by cryo-transmission electron microscopy. The encapsulation efficiency was 94.2±2.8% for ethosomes and 53.2±0.2% for solid lipid nanoparticle. Concerning Z potential, both formulations are close to neutrality. The diffusion coefficients of the drug from ethosomes and solid lipid nanoparticle, determined by a Franz cell method, were 9.4 and 1.2-fold lower as compared to the free acyclovir in solution, thus evidencing the ability of both colloidal systems in enhancing the diffusion of the drug. The antiviral activity against HSV-1 of both systems was tested by plaque reduction assay in monolayer cultures of Vero cells. Data showed that no significant differences in the antiviral activity were observed by acyclovir in the free or loaded forms. Taken together these results, colloidal systems could be interesting to mediate the penetration of acyclovir within Vero cells. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3480758/ /pubmed/23112407 http://dx.doi.org/10.4103/0250-474X.100253 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Cortesi, Rita
Ravani, Laura
Menegatti, Enea
Drechsler, M.
Esposito, Elisabetta
Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study
title Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study
title_full Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study
title_fullStr Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study
title_full_unstemmed Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study
title_short Colloidal Dispersions for the Delivery of Acyclovir: A Comparative Study
title_sort colloidal dispersions for the delivery of acyclovir: a comparative study
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480758/
https://www.ncbi.nlm.nih.gov/pubmed/23112407
http://dx.doi.org/10.4103/0250-474X.100253
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