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Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis
The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480807/ https://www.ncbi.nlm.nih.gov/pubmed/23115606 http://dx.doi.org/10.2174/1874325001206010458 |
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author | Haba, Yvonne Lindner, Tobias Fritsche, Andreas Schiebenhöfer, Ann-Kristin Souffrant, Robert Kluess, Daniel Skripitz, Ralf Mittelmeier, Wolfram Bader, Rainer |
author_facet | Haba, Yvonne Lindner, Tobias Fritsche, Andreas Schiebenhöfer, Ann-Kristin Souffrant, Robert Kluess, Daniel Skripitz, Ralf Mittelmeier, Wolfram Bader, Rainer |
author_sort | Haba, Yvonne |
collection | PubMed |
description | The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a maximum of 24 hours postoperatively at + 6 °C to 8 °C. Analysis revealed an average structural modulus of 232±130 N/mm(2) and ultimate compression strength of 6.1±3.3 N/mm(2) with high standard deviations. Bone mineral densities of 385±133 mg/cm(2) and 353±172 mg/cm(3) were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm(3). In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22). Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements. |
format | Online Article Text |
id | pubmed-3480807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-34808072012-10-31 Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis Haba, Yvonne Lindner, Tobias Fritsche, Andreas Schiebenhöfer, Ann-Kristin Souffrant, Robert Kluess, Daniel Skripitz, Ralf Mittelmeier, Wolfram Bader, Rainer Open Orthop J Article The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a maximum of 24 hours postoperatively at + 6 °C to 8 °C. Analysis revealed an average structural modulus of 232±130 N/mm(2) and ultimate compression strength of 6.1±3.3 N/mm(2) with high standard deviations. Bone mineral densities of 385±133 mg/cm(2) and 353±172 mg/cm(3) were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm(3). In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22). Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements. Bentham Open 2012-10-19 /pmc/articles/PMC3480807/ /pubmed/23115606 http://dx.doi.org/10.2174/1874325001206010458 Text en © Haba et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Haba, Yvonne Lindner, Tobias Fritsche, Andreas Schiebenhöfer, Ann-Kristin Souffrant, Robert Kluess, Daniel Skripitz, Ralf Mittelmeier, Wolfram Bader, Rainer Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis |
title | Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis |
title_full | Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis |
title_fullStr | Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis |
title_full_unstemmed | Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis |
title_short | Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis |
title_sort | relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480807/ https://www.ncbi.nlm.nih.gov/pubmed/23115606 http://dx.doi.org/10.2174/1874325001206010458 |
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