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Thyroid functions of neonates with Down syndrome

BACKGROUND: We aimed to evaluate thyroid functions and volumes and detect abnormalities in 80 neonates with Down syndrome. METHODS: Data about free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroglobulin and urinary iodine levels, and ultrasonographic thyroid volume were collect...

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Autores principales: Sarici, Dilek, Akin, Mustafa Ali, Kurtoglu, Selim, Gunes, Tamer, Ozturk, Mehmet Adnan, Akcakus, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480826/
https://www.ncbi.nlm.nih.gov/pubmed/22985522
http://dx.doi.org/10.1186/1824-7288-38-44
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author Sarici, Dilek
Akin, Mustafa Ali
Kurtoglu, Selim
Gunes, Tamer
Ozturk, Mehmet Adnan
Akcakus, Mustafa
author_facet Sarici, Dilek
Akin, Mustafa Ali
Kurtoglu, Selim
Gunes, Tamer
Ozturk, Mehmet Adnan
Akcakus, Mustafa
author_sort Sarici, Dilek
collection PubMed
description BACKGROUND: We aimed to evaluate thyroid functions and volumes and detect abnormalities in 80 neonates with Down syndrome. METHODS: Data about free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroglobulin and urinary iodine levels, and ultrasonographic thyroid volume were collected. RESULTS: Abnormal thyroid function tests were detected in 53.8% of the patients (n = 50) and these were hyperthyrotropinemia, hypothyroidism, iodine deficiency and iodine overload in 32, 2, 12 and 4 patients, respectively. Thyroid volumes were assessed in 36 patients and a total of 17 abnormalities were detected (7 hypoplasia, 3 agenesis and 7 goiter). In patients with hyperthyrotropinemia mean thyroid volume was significantly greater and mean TSH was significantly higher when compared to the patients without hyperthyrotropinemia. CONCLUSION: Neonatal screening by thyroid function tests in Down syndrome should be performed to prevent further intellectual deterioration and improve overall development. In the neonatal period, the risk of hyperthyrotropinemia should be kept in mind.
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spelling pubmed-34808262012-10-27 Thyroid functions of neonates with Down syndrome Sarici, Dilek Akin, Mustafa Ali Kurtoglu, Selim Gunes, Tamer Ozturk, Mehmet Adnan Akcakus, Mustafa Ital J Pediatr Research BACKGROUND: We aimed to evaluate thyroid functions and volumes and detect abnormalities in 80 neonates with Down syndrome. METHODS: Data about free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroglobulin and urinary iodine levels, and ultrasonographic thyroid volume were collected. RESULTS: Abnormal thyroid function tests were detected in 53.8% of the patients (n = 50) and these were hyperthyrotropinemia, hypothyroidism, iodine deficiency and iodine overload in 32, 2, 12 and 4 patients, respectively. Thyroid volumes were assessed in 36 patients and a total of 17 abnormalities were detected (7 hypoplasia, 3 agenesis and 7 goiter). In patients with hyperthyrotropinemia mean thyroid volume was significantly greater and mean TSH was significantly higher when compared to the patients without hyperthyrotropinemia. CONCLUSION: Neonatal screening by thyroid function tests in Down syndrome should be performed to prevent further intellectual deterioration and improve overall development. In the neonatal period, the risk of hyperthyrotropinemia should be kept in mind. BioMed Central 2012-09-17 /pmc/articles/PMC3480826/ /pubmed/22985522 http://dx.doi.org/10.1186/1824-7288-38-44 Text en Copyright ©2012 Sarici et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Sarici, Dilek
Akin, Mustafa Ali
Kurtoglu, Selim
Gunes, Tamer
Ozturk, Mehmet Adnan
Akcakus, Mustafa
Thyroid functions of neonates with Down syndrome
title Thyroid functions of neonates with Down syndrome
title_full Thyroid functions of neonates with Down syndrome
title_fullStr Thyroid functions of neonates with Down syndrome
title_full_unstemmed Thyroid functions of neonates with Down syndrome
title_short Thyroid functions of neonates with Down syndrome
title_sort thyroid functions of neonates with down syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480826/
https://www.ncbi.nlm.nih.gov/pubmed/22985522
http://dx.doi.org/10.1186/1824-7288-38-44
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