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Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the Topoisomerase II inhibitor, Etoposide, in rice

BACKGROUND: Etoposide (epipodophyllotoxin) is a chemical commonly used as an anti-cancer drug which inhibits DNA synthesis by blocking topoisomerase II activity. Previous studies in animal cells have demonstrated that etoposide constitutes a genotoxic stress which may induce genomic instability incl...

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Detalles Bibliográficos
Autores principales: Yang, Xuejiao, Yu, Yingjie, Jiang, Lily, Lin, Xiuyun, Zhang, Chunyu, Ou, Xiufang, Osabe, Kenji, Liu, Bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480845/
https://www.ncbi.nlm.nih.gov/pubmed/22482475
http://dx.doi.org/10.1186/1471-2229-12-48