Cargando…

Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia

BACKGROUND: Role of KRAS, BRAF and PIK3CA mutations in pathogenesis of colorectal cancer (CRC) has been recently investigated worldwide. In this population-based study, we evaluated the incidence rates and distribution of such somatic mutations in genetically isolated population from Sardinia. METHO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palomba, Grazia, Colombino, Maria, Contu, Antonio, Massidda, Bruno, Baldino, Giovanni, Pazzola, Antonio, Ionta, MariaTeresa, Capelli, Francesca, Trova, Vittorio, Sedda, Tito, Sanna, Giovanni, Tanda, Francesco, Budroni, Mario, Palmieri, Giuseppe, Cossu, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480926/ https://www.ncbi.nlm.nih.gov/pubmed/22931052 http://dx.doi.org/10.1186/1479-5876-10-178

Ejemplares similares

Triple-negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia
por: PALOMBA, GRAZIA, et al.
Publicado: (2014)

Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study
por: Palomba, Grazia, et al.
Publicado: (2016)

Prognostic role of KRAS mutations in Sardinian patients with colorectal carcinoma
por: Palomba, Grazia, et al.
Publicado: (2016)

Lung cancer epidemiology in North Sardinia, Italy
por: Paliogiannis, Panagiotis, et al.
Publicado: (2013)

Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia
por: Budroni, Mario, et al.
Publicado: (2009)

Molecular alterations in key-regulator genes among patients with T4 breast carcinoma
por: Massidda, Bruno, et al.
Publicado: (2010)

ERCC1 polymorphisms as prognostic markers in T4 breast cancer patients treated with platinum-based chemotherapy
por: Palomba, Grazia, et al.
Publicado: (2014)

Origin and distribution of the BRCA2-8765delAG mutation in breast cancer
por: Palomba, Grazia, et al.
Publicado: (2007)

Identification of a founder BRCA2 mutation in Sardinia
por: Pisano, M, et al.
Publicado: (2000)

Impact of tissue type and content of neoplastic cells of samples on the quality of epidermal growth factor receptor mutation analysis among patients with lung adenocarcinoma
por: PALIOGIANNIS, PANAGIOTIS, et al.
Publicado: (2015)

KRAS mutational concordance between primary and metastatic colorectal adenocarcinoma
por: PALIOGIANNIS, PANAGIOTIS, et al.
Publicado: (2014)

Low Prevalence of HPV Related Oropharyngeal Carcinogenesis in Northern Sardinia
por: Bussu, Francesco, et al.
Publicado: (2022)

Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas
por: Manca, Antonella, et al.
Publicado: (2015)

Liquid Biopsy in the Oncological Management of a Histologically Undiagnosed Lung Carcinoma: A Case Report
por: Fadda, Giovanni M., et al.
Publicado: (2022)

Epidemiology of Thyroid Cancer in an Area of Epidemic Thyroid Goiter
por: Cossu, Antonio, et al.
Publicado: (2013)

A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population
por: Palomba, Grazia, et al.
Publicado: (2009)

KIT and PDGFRa mutational patterns in Sardinian patients with gastrointestinal stromal tumors
por: Palomba, Grazia, et al.
Publicado: (2020)

Knowledge about cancer screening programmes in Sardinia
por: MEREU, A., et al.
Publicado: (2019)

Mendelian breeding units versus standard sampling strategies: Mitochondrial DNA variation in southwest Sardinia
por: Sanna, Daria, et al.
Publicado: (2011)

MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia
por: Floris, Matteo, et al.
Publicado: (2020)

Perivascular Epithelioid Cell Tumors (PEComas) of the Orbit
por: Paliogiannis, Panagiotis, et al.
Publicado: (2017)

Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology
por: Muresu, Narcisa, et al.
Publicado: (2022)

Primary Dermal Melanoma in a Patient with a History of Multiple Malignancies: A Case Report with Molecular Characterization
por: Sini, Germana, et al.
Publicado: (2013)

Genetic Characterization of Echinococcus granulosus sensu stricto Isolated from Human Cysts from Sardinia, Italy
por: Santucciu, Cinzia, et al.
Publicado: (2023)

Vitamin D status and risk for malignant cutaneous melanoma: recent advances
por: Ombra, Maria N., et al.
Publicado: (2017)

Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
por: Palmieri, Giuseppe, et al.
Publicado: (2017)

Global prognostic impact of driver genetic alterations in patients with lung adenocarcinoma: a real-life study
por: Paliogiannis, Panagiotis, et al.
Publicado: (2022)

Molecular detection of Theileria sergentii/orientalis/buffeli and Ehrlichia canis from aborted ovine and caprine products in Sardinia, Italy
por: Chisu, Valentina, et al.
Publicado: (2021)

Employing a spatio-temporal contingency table for the analysis of cork oak cover change in the Sa Serra region of Sardinia
por: Dettori, Sandro, et al.
Publicado: (2018)

Molecular Pathways in Melanomagenesis: What We Learned from Next-Generation Sequencing Approaches
por: Palmieri, Giuseppe, et al.
Publicado: (2018)

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy
por: Casula, Milena, et al.
Publicado: (2009)

Serial detection of circulating tumour cells by reverse transcriptase-polymerase chain reaction assays is a marker for poor outcome in patients with malignant melanoma
por: Palmieri, Giuseppe, et al.
Publicado: (2006)

Retrospective study of lameness in beef cattle in northeastern Sardinia, Italy
por: Morrone, Sarah, et al.
Publicado: (2023)

EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma
por: Colombino, Maria, et al.
Publicado: (2019)

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report
por: Pulighe, Fabio, et al.
Publicado: (2013)

A Whole-Genome Sequencing-Based Approach for the Characterization of Klebsiella pneumoniae Co-Producing KPC and OXA-48-like Carbapenemases Circulating in Sardinia, Italy
por: Del Rio, Arcadia, et al.
Publicado: (2023)

First Record of the Alien Species Procambarus virginalis Lyko, 2017 in Fresh Waters of Sardinia and Insight into Its Genetic Variability
por: Sanna, Daria, et al.
Publicado: (2021)

Seroprevalence and risk factors associated with Leishmania infantum in dogs in Sardinia (Italy), an endemic island for leishmaniasis
por: Tamponi, Claudia, et al.
Publicado: (2020)

Broadening the phenotype of TARDBP mutations: the TARDBP Ala382Thr mutation and Parkinson’s disease in Sardinia
por: Quadri, Marialuisa, et al.
Publicado: (2011)

Recognition of Zinc Transporter 8 and MAP3865c Homologous Epitopes by Hashimoto's Thyroiditis Subjects from Sardinia: A Common Target with Type 1 Diabetes?
por: Masala, Speranza, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_egelc5lhd8tm8teaveos3gidku