CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model

The chemokine receptor CXCR4 favors the interaction of acute myeloid leukemia (AML) cells with their niche but the extent to which it participates in pathogenesis is unclear. Here, we show that CXCR4 expression at the surface of leukemic cells allowed distinguishing CXCR4(high) from CXCR4(neg/low) A...

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Detalles Bibliográficos
Autores principales: Zhang, Y, Patel, S, Abdelouahab, H, Wittner, M, Willekens, C, Shen, S, Betems, A, Joulin, V, Opolon, P, Bawa, O, Pasquier, F, Ito, M, Fujii, N, Gonin, P, Solary, E, Vainchenker, W, Coppo, P, De Botton, S, Louache, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481125/
https://www.ncbi.nlm.nih.gov/pubmed/23034331
http://dx.doi.org/10.1038/cddis.2012.137

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