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BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression

Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, ow...

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Detalles Bibliográficos
Autores principales:	Persano, L, Pistollato, F, Rampazzo, E, Della Puppa, A, Abbadi, S, Frasson, C, Volpin, F, Indraccolo, S, Scienza, R, Basso, G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481140/ https://www.ncbi.nlm.nih.gov/pubmed/23076220 http://dx.doi.org/10.1038/cddis.2012.153

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