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The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease

This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was m...

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Autores principales: Ohuma, E. O., Okiro, E. A., Ochola, R., Sande, C. J., Cane, P. A., Medley, G. F., Bottomley, C., Nokes, D. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481264/
https://www.ncbi.nlm.nih.gov/pubmed/23059788
http://dx.doi.org/10.1093/aje/kws257
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author Ohuma, E. O.
Okiro, E. A.
Ochola, R.
Sande, C. J.
Cane, P. A.
Medley, G. F.
Bottomley, C.
Nokes, D. J.
author_facet Ohuma, E. O.
Okiro, E. A.
Ochola, R.
Sande, C. J.
Cane, P. A.
Medley, G. F.
Bottomley, C.
Nokes, D. J.
author_sort Ohuma, E. O.
collection PubMed
description This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a “most pragmatic” serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related.
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spelling pubmed-34812642012-10-26 The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease Ohuma, E. O. Okiro, E. A. Ochola, R. Sande, C. J. Cane, P. A. Medley, G. F. Bottomley, C. Nokes, D. J. Am J Epidemiol Original Contributions This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a “most pragmatic” serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related. Oxford University Press 2012-11-01 2012-10-11 /pmc/articles/PMC3481264/ /pubmed/23059788 http://dx.doi.org/10.1093/aje/kws257 Text en © The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Contributions
Ohuma, E. O.
Okiro, E. A.
Ochola, R.
Sande, C. J.
Cane, P. A.
Medley, G. F.
Bottomley, C.
Nokes, D. J.
The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease
title The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease
title_full The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease
title_fullStr The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease
title_full_unstemmed The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease
title_short The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease
title_sort natural history of respiratory syncytial virus in a birth cohort: the influence of age and previous infection on reinfection and disease
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481264/
https://www.ncbi.nlm.nih.gov/pubmed/23059788
http://dx.doi.org/10.1093/aje/kws257
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