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The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry

The sigma-1 receptor (Sig1R) is up-regulated in many human tumors and plays a role in the control of cancer cell proliferation and invasiveness. At the molecular level, the Sig1R modulates the activity of various ion channels, apparently through a direct interaction. We have previously shown using a...

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Detalles Bibliográficos
Autores principales:	Balasuriya, Dilshan, Stewart, Andrew P., Crottès, David, Borgese, Franck, Soriani, Olivier, Edwardson, J. Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481303/ https://www.ncbi.nlm.nih.gov/pubmed/22952230 http://dx.doi.org/10.1074/jbc.M112.382077

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