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Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia
BACKGROUND: Robot-generated deviating forces during multijoint reaching movements have been applied to investigate motor control and to tune neuromotor adaptation. Can the application of force to limbs improve motor learning? In this framework, the response to altered dynamic environments of childre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481357/ https://www.ncbi.nlm.nih.gov/pubmed/22824547 http://dx.doi.org/10.1186/1743-0003-9-46 |
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author | Casellato, Claudia Pedrocchi, Alessandra Zorzi, Giovanna Rizzi, Giorgio Ferrigno, Giancarlo Nardocci, Nardo |
author_facet | Casellato, Claudia Pedrocchi, Alessandra Zorzi, Giovanna Rizzi, Giorgio Ferrigno, Giancarlo Nardocci, Nardo |
author_sort | Casellato, Claudia |
collection | PubMed |
description | BACKGROUND: Robot-generated deviating forces during multijoint reaching movements have been applied to investigate motor control and to tune neuromotor adaptation. Can the application of force to limbs improve motor learning? In this framework, the response to altered dynamic environments of children affected by primary dystonia has never been studied. METHODS: As preliminary pilot study, eleven children with primary dystonia and eleven age-matched healthy control subjects were asked to perform upper limb movements, triangle-reaching (three directions) and circle-writing, using a haptic robot interacting with ad-hoc developed task-specific visual interfaces. Three dynamic conditions were provided, null additive external force (A), constant disturbing force (B) and deactivation of the additive external force again (C). The path length for each trial was computed, from the recorded position data and interaction events. RESULTS: The results show that the disturbing force affects significantly the movement outcomes in healthy but not in dystonic subjects, already compromised in the reference condition: the external alteration uncalibrates the healthy sensorimotor system, while the dystonic one is already strongly uncalibrated. The lack of systematic compensation for perturbation effects during B condition is reflected into the absence of after-effects in C condition, which would be the evidence that CNS generates a prediction of the perturbing forces using an internal model of the environment. The most promising finding is that in dystonic population the altered dynamic exposure seems to induce a subsequent improvement, i.e. a beneficial after-effect in terms of optimal path control, compared with the correspondent reference movement outcome. CONCLUSIONS: The short-time error-enhancing training in dystonia could represent an effective approach for motor performance improvement, since the exposure to controlled dynamic alterations induces a refining of the existing but strongly imprecise motor scheme and sensorimotor patterns. |
format | Online Article Text |
id | pubmed-3481357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34813572012-10-27 Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia Casellato, Claudia Pedrocchi, Alessandra Zorzi, Giovanna Rizzi, Giorgio Ferrigno, Giancarlo Nardocci, Nardo J Neuroeng Rehabil Research BACKGROUND: Robot-generated deviating forces during multijoint reaching movements have been applied to investigate motor control and to tune neuromotor adaptation. Can the application of force to limbs improve motor learning? In this framework, the response to altered dynamic environments of children affected by primary dystonia has never been studied. METHODS: As preliminary pilot study, eleven children with primary dystonia and eleven age-matched healthy control subjects were asked to perform upper limb movements, triangle-reaching (three directions) and circle-writing, using a haptic robot interacting with ad-hoc developed task-specific visual interfaces. Three dynamic conditions were provided, null additive external force (A), constant disturbing force (B) and deactivation of the additive external force again (C). The path length for each trial was computed, from the recorded position data and interaction events. RESULTS: The results show that the disturbing force affects significantly the movement outcomes in healthy but not in dystonic subjects, already compromised in the reference condition: the external alteration uncalibrates the healthy sensorimotor system, while the dystonic one is already strongly uncalibrated. The lack of systematic compensation for perturbation effects during B condition is reflected into the absence of after-effects in C condition, which would be the evidence that CNS generates a prediction of the perturbing forces using an internal model of the environment. The most promising finding is that in dystonic population the altered dynamic exposure seems to induce a subsequent improvement, i.e. a beneficial after-effect in terms of optimal path control, compared with the correspondent reference movement outcome. CONCLUSIONS: The short-time error-enhancing training in dystonia could represent an effective approach for motor performance improvement, since the exposure to controlled dynamic alterations induces a refining of the existing but strongly imprecise motor scheme and sensorimotor patterns. BioMed Central 2012-07-23 /pmc/articles/PMC3481357/ /pubmed/22824547 http://dx.doi.org/10.1186/1743-0003-9-46 Text en Copyright ©2012 Casellato et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Casellato, Claudia Pedrocchi, Alessandra Zorzi, Giovanna Rizzi, Giorgio Ferrigno, Giancarlo Nardocci, Nardo Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
title | Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
title_full | Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
title_fullStr | Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
title_full_unstemmed | Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
title_short | Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
title_sort | error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481357/ https://www.ncbi.nlm.nih.gov/pubmed/22824547 http://dx.doi.org/10.1186/1743-0003-9-46 |
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