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Immunophenotypes of Glycogen Rich Clear Cell Carcinoma

PURPOSE: Glycogen rich clear cell carcinoma (GRCC) of the breast is a rare subtype of invasive ductal carcinoma and involves a poor prognosis. In the literature, less than 150 cases have been reported. Many researchers have attempted to characterize GRCC according to electron microscope, flow cytome...

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Autores principales: Kim, Sung Eun, Koo, Ja Seung, Jung, Woo-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481379/
https://www.ncbi.nlm.nih.gov/pubmed/23074114
http://dx.doi.org/10.3349/ymj.2012.53.6.1142
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author Kim, Sung Eun
Koo, Ja Seung
Jung, Woo-Hee
author_facet Kim, Sung Eun
Koo, Ja Seung
Jung, Woo-Hee
author_sort Kim, Sung Eun
collection PubMed
description PURPOSE: Glycogen rich clear cell carcinoma (GRCC) of the breast is a rare subtype of invasive ductal carcinoma and involves a poor prognosis. In the literature, less than 150 cases have been reported. Many researchers have attempted to characterize GRCC according to electron microscope, flow cytometry, or clinical data. However, an organized study of the immunophenotype of GRCC has yet to be reported. MATERIALS AND METHODS: Here, we present three cases of GRCC and their immunohistochemical profiles. RESULTS: Histologically, all three cases contained periodic acid stain (PAS) positive and d-PAS labile granules in their clear cytoplasm. Case I showed positivity for only estrogen receptor (ER) and c-erbB2. Case II exhibited positivity for progesterone receptor and negativity for ER and c-erbB2. Case III presented with triple negative invasive carcinoma. The expression pattern of E-cadherin was concordant with epidermal growth factor receptor and c-kit, but discordant with ki-67. Among these three cases, p53-positive cases exhibited a low proliferative index (ki-67: 15%), while p53-negative cases showed a high proliferative index (ki-67: 50-60%). CONCLUSION: In conclusion, the immunophenotype of GRCC is not uniform, but is similar to that of conventional ductal carcinoma.
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spelling pubmed-34813792012-11-01 Immunophenotypes of Glycogen Rich Clear Cell Carcinoma Kim, Sung Eun Koo, Ja Seung Jung, Woo-Hee Yonsei Med J Original Article PURPOSE: Glycogen rich clear cell carcinoma (GRCC) of the breast is a rare subtype of invasive ductal carcinoma and involves a poor prognosis. In the literature, less than 150 cases have been reported. Many researchers have attempted to characterize GRCC according to electron microscope, flow cytometry, or clinical data. However, an organized study of the immunophenotype of GRCC has yet to be reported. MATERIALS AND METHODS: Here, we present three cases of GRCC and their immunohistochemical profiles. RESULTS: Histologically, all three cases contained periodic acid stain (PAS) positive and d-PAS labile granules in their clear cytoplasm. Case I showed positivity for only estrogen receptor (ER) and c-erbB2. Case II exhibited positivity for progesterone receptor and negativity for ER and c-erbB2. Case III presented with triple negative invasive carcinoma. The expression pattern of E-cadherin was concordant with epidermal growth factor receptor and c-kit, but discordant with ki-67. Among these three cases, p53-positive cases exhibited a low proliferative index (ki-67: 15%), while p53-negative cases showed a high proliferative index (ki-67: 50-60%). CONCLUSION: In conclusion, the immunophenotype of GRCC is not uniform, but is similar to that of conventional ductal carcinoma. Yonsei University College of Medicine 2012-11-01 2012-10-05 /pmc/articles/PMC3481379/ /pubmed/23074114 http://dx.doi.org/10.3349/ymj.2012.53.6.1142 Text en © Copyright: Yonsei University College of Medicine 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Sung Eun
Koo, Ja Seung
Jung, Woo-Hee
Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
title Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
title_full Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
title_fullStr Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
title_full_unstemmed Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
title_short Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
title_sort immunophenotypes of glycogen rich clear cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481379/
https://www.ncbi.nlm.nih.gov/pubmed/23074114
http://dx.doi.org/10.3349/ymj.2012.53.6.1142
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