Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation

BACKGROUND: 2,4-Dimethoxyphenyl-E-4-arylidene-3-isochromanone (IK11) was previously described to induce apoptotic death of A431 tumor cells. In this report, we investigated the molecular action of IK11 in the HepG2 human hepatocellular carcinoma cell line to increase our knowledge of the role of pol...

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Detalles Bibliográficos
Autores principales: Radnai, Balazs, Antus, Csenge, Racz, Boglarka, Engelmann, Peter, Priber, Janos Krisztian, Tucsek, Zsuzsanna, Veres, Balazs, Turi, Zsuzsanna, Lorand, Tamas, Sumegi, Balazs, Gallyas, Ferenc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481453/
https://www.ncbi.nlm.nih.gov/pubmed/22583868
http://dx.doi.org/10.1186/1476-4598-11-34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481453/
https://www.ncbi.nlm.nih.gov/pubmed/22583868
http://dx.doi.org/10.1186/1476-4598-11-34

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