Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

[Image: see text] Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterost...

Descripción completa

Detalles Bibliográficos
Autores principales: Carr, Gavin, Derbyshire, Emily R., Caldera, Eric, Currie, Cameron R., Clardy, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481556/
https://www.ncbi.nlm.nih.gov/pubmed/23025282
http://dx.doi.org/10.1021/np300380t
Descripción
Sumario:[Image: see text] Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1–3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.

Ejemplares similares