Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

[Image: see text] Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterost...

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Autores principales: Carr, Gavin, Derbyshire, Emily R., Caldera, Eric, Currie, Cameron R., Clardy, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481556/
https://www.ncbi.nlm.nih.gov/pubmed/23025282
http://dx.doi.org/10.1021/np300380t
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author Carr, Gavin
Derbyshire, Emily R.
Caldera, Eric
Currie, Cameron R.
Clardy, Jon
author_facet Carr, Gavin
Derbyshire, Emily R.
Caldera, Eric
Currie, Cameron R.
Clardy, Jon
author_sort Carr, Gavin
collection PubMed
description [Image: see text] Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1–3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.
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spelling pubmed-34815562012-10-26 Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp. Carr, Gavin Derbyshire, Emily R. Caldera, Eric Currie, Cameron R. Clardy, Jon J Nat Prod [Image: see text] Three new members of the angucycline class of antibiotics, pseudonocardones A–C (1–3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1–3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells. American Chemical Society and American Society of Pharmacognosy 2012-10-01 2012-10-26 /pmc/articles/PMC3481556/ /pubmed/23025282 http://dx.doi.org/10.1021/np300380t Text en Copyright © 2012 American Chemical Society and American Society of Pharmacognosy http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Carr, Gavin
Derbyshire, Emily R.
Caldera, Eric
Currie, Cameron R.
Clardy, Jon
Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
title Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
title_full Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
title_fullStr Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
title_full_unstemmed Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
title_short Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.
title_sort antibiotic and antimalarial quinones from fungus-growing ant-associated pseudonocardia sp.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481556/
https://www.ncbi.nlm.nih.gov/pubmed/23025282
http://dx.doi.org/10.1021/np300380t
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